Protein Info for MPMX19_00076 in Azospirillum sp. SherDot2

Annotation: 3-methylmercaptopropionyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 PF12418: AcylCoA_DH_N" amino acids 8 to 38 (31 residues), 39.7 bits, see alignment (E = 1.4e-13) PF02771: Acyl-CoA_dh_N" amino acids 86 to 161 (76 residues), 39.3 bits, see alignment E=2.6e-13 PF02770: Acyl-CoA_dh_M" amino acids 167 to 274 (108 residues), 44.1 bits, see alignment E=6.8e-15 PF00441: Acyl-CoA_dh_1" amino acids 288 to 457 (170 residues), 99.9 bits, see alignment E=5.4e-32 PF08028: Acyl-CoA_dh_2" amino acids 305 to 446 (142 residues), 27.4 bits, see alignment E=1.3e-09 PF12806: Acyl-CoA_dh_C" amino acids 471 to 597 (127 residues), 101.1 bits, see alignment E=1.7e-32

Best Hits

KEGG orthology group: None (inferred from 91% identity to azl:AZL_026060)

Predicted SEED Role

"Acyl-CoA dehydrogenase (EC 1.3.8.7)" (EC 1.3.8.7)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.7

Use Curated BLAST to search for 1.3.8.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (606 amino acids)

>MPMX19_00076 3-methylmercaptopropionyl-CoA dehydrogenase (Azospirillum sp. SherDot2)
MTAAAIPYTPPLKEIRFVLDHLAGMAEVAALPGFEDASPDMVDSILGEAAKIAENVLAPL
NRIGDVQGAKLGTDGVARTAEGWGTAWQALVEGGWNGLPFDPARGGMGLPNLLNTAVQEM
WHSANMAFALCPMLTQGAVNAVQLYGSEALKDLYLPRMISGGWTGTMNITEPQAGSDLAA
TRSRAVPNGDHYLVTGQKIFITYGDHDLTENIVHLVLARLPDAPPGVKGISLFVVPKFLV
NPDGSLGARNQVKCVSLEHKLGIHGSPTAVLSFGDEGGATGFLVGEPNRGLEYMFAMMNH
ARLNVAMQGLAIAERAYQQALAYARDRVQGKPLGWTEGQSKGIVNHPDVRRLLMGMKARI
EAMRGILYTAAAAVDVAHHHADEATRGRAALLVDLLTPIAKGWCTETGQQLASDGVQVHG
GMGFIEETGAAQHLRDARITTIYEGTTAIQANDLINRKLLRDGGAMANGLLDEIAALAGE
LSGHTDEALRVTGAELVGAVHEAKQAIAWVLATAKQDPRLPAAASVTLLELMGVVAGGWQ
LARAAKVATERLAGGDADTAFLSAKPLTARFYATHVLPKAAALRATVVNGSASVMALSEE
QLFGAV