Protein Info for MIT1002_04044 in Alteromonas macleodii MIT1002

Annotation: HTH-type transcriptional regulator GltC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00126: HTH_1" amino acids 5 to 63 (59 residues), 57.8 bits, see alignment E=8.4e-20 PF03466: LysR_substrate" amino acids 90 to 286 (197 residues), 130.1 bits, see alignment E=7.8e-42

Best Hits

Swiss-Prot: 45% identical to ILVY_HAEIN: HTH-type transcriptional activator IlvY (ilvY) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K02521, LysR family transcriptional regulator, positive regulator for ilvC (inferred from 97% identity to amc:MADE_04020)

Predicted SEED Role

"HTH-type transcriptional regulator IlvY" in subsystem Alanine biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>MIT1002_04044 HTH-type transcriptional regulator GltC (Alteromonas macleodii MIT1002)
MFMDFRSLQLFNHLATSLHFGITAEAMYVSPSTLSRVIQRLEDELSCTLFKRDNRKVALT
HSGHKLLSFSKQALKDWQQLKVDLKEDNDALQGELSVFCSVTASQSHLPAMLRQFRQQHP
GVDIRLITGDPALAIEKVKGKQCDLSIAIYTPDMPTDLHFTALDNVPLVLIAPREWRLTQ
LSQLDWTKHQVIMPETGPTRRTAYHWFAEHGIRPNVYAYVGGNEAIVSMVALECGVGFVP
KVVLDHSSMANAVTQIPVEDIEPYALGLCCLQDKQNEPLINAFMQLNLQTRG