Protein Info for MIT1002_04035 in Alteromonas macleodii MIT1002

Annotation: Cytochrome c oxidase subunit 2 precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 387 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 54 to 77 (24 residues), see Phobius details amino acids 97 to 119 (23 residues), see Phobius details PF02790: COX2_TM" amino acids 34 to 114 (81 residues), 46 bits, see alignment E=9.5e-16 TIGR02866: cytochrome c oxidase, subunit II" amino acids 43 to 261 (219 residues), 185.6 bits, see alignment E=4.1e-59 PF00116: COX2" amino acids 129 to 249 (121 residues), 122.8 bits, see alignment E=1.5e-39 PF13442: Cytochrome_CBB3" amino acids 289 to 362 (74 residues), 47.3 bits, see alignment E=4.1e-16 PF00034: Cytochrom_C" amino acids 290 to 362 (73 residues), 31.5 bits, see alignment E=7.7e-11

Best Hits

KEGG orthology group: K02275, cytochrome c oxidase subunit II [EC: 1.9.3.1] (inferred from 95% identity to amc:MADE_04013)

MetaCyc: 60% identical to cytochrome c oxidase subunit 2 (Pseudomonas putida KT2440)

Predicted SEED Role

"Cytochrome c oxidase polypeptide II (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (387 amino acids)

>MIT1002_04035 Cytochrome c oxidase subunit 2 precursor (Alteromonas macleodii MIT1002)
MKQLTTVFAKWCSSIPILLFSPLLFAQEASEEASSLNLRRGATDISGQVYDLHMLMFFIC
VGIAVVVFGVMFASMYLHRKSRGAKPANFHENVKVEIAWTVIPFLILIFMAVPAANTLIA
MEDTSEPDMTVLVTGSQWKWHYKYMDSDVEFYSLLATQREQIENKFQKTDNYLLEVDRPL
VIPTGKKVRFLITSDDVIHSWWVPDFAVKKDANPGFINESWAKVNEPGIYRGQCAELCGK
DHGYMPVVVIAKEPAEFDKWMGEQEEIVRKAKEEEQRLLSMNMSMDELMKEGERVYNATC
AACHMPNGEGLPGVFPALKGSKMALEDQQGHIDIVLHGKSGTAMQAFGKMLSLKEIAAVV
TYERNAWGNKTGDMVQAKDVNAVANGN