Protein Info for MIT1002_03956 in Alteromonas macleodii MIT1002

Annotation: Ribosomal protein L11 methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 292 TIGR00406: ribosomal protein L11 methyltransferase" amino acids 3 to 284 (282 residues), 329.6 bits, see alignment E=9.2e-103 PF06325: PrmA" amino acids 3 to 291 (289 residues), 334.5 bits, see alignment E=3.5e-103 PF05175: MTS" amino acids 144 to 229 (86 residues), 38.3 bits, see alignment E=5.6e-13 PF01728: FtsJ" amino acids 156 to 230 (75 residues), 24.3 bits, see alignment E=1.4e-08 PF13847: Methyltransf_31" amino acids 159 to 229 (71 residues), 36.7 bits, see alignment E=1.7e-12 PF02475: TRM5-TYW2_MTfase" amino acids 160 to 228 (69 residues), 29.8 bits, see alignment E=3e-10 PF13649: Methyltransf_25" amino acids 162 to 214 (53 residues), 36.3 bits, see alignment 3.9e-12 PF08241: Methyltransf_11" amino acids 163 to 210 (48 residues), 30.2 bits, see alignment 2.9e-10 PF08242: Methyltransf_12" amino acids 163 to 235 (73 residues), 32 bits, see alignment E=8.3e-11

Best Hits

Swiss-Prot: 92% identical to PRMA_ALTMD: Ribosomal protein L11 methyltransferase (prmA) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K02687, ribosomal protein L11 methyltransferase [EC: 2.1.1.-] (inferred from 92% identity to amc:MADE_03936)

MetaCyc: 63% identical to ribosomal protein L11 methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN0-5419

Predicted SEED Role

"Ribosomal protein L11 methyltransferase (EC 2.1.1.-)" in subsystem Heat shock dnaK gene cluster extended or Ribosome biogenesis bacterial (EC 2.1.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.-

Use Curated BLAST to search for 2.1.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (292 amino acids)

>MIT1002_03956 Ribosomal protein L11 methyltransferase (Alteromonas macleodii MIT1002)
MAWLQLRINTSSEHAESIGDMLTANGSQAVTYVDAKDTPMYEPKPGEVLLWPDTQVVGLF
EADADMKGILQRLGKAKILGPDFKYKLEPLEDKDWEREWMDNFHPMQFGERLWICPSWRD
VPDPNAVNVMLDPGLAFGTGTHPTTALCLRWLDGIDMTDKTVVDFGCGSGILALAALKLG
AKRVIGIDIDPQALQATKENARRNGVEDRLDVYLPEDQPELEADVVMANILSGPLLELQS
VITNYCKSGGLLVLSGILAEQVTRIEEAYANDITLEPSAIDGEWARVSGKKQ