Protein Info for MIT1002_03939 in Alteromonas macleodii MIT1002

Annotation: Thiol:disulfide interchange protein DsbD precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 628 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 205 to 231 (27 residues), see Phobius details amino acids 248 to 273 (26 residues), see Phobius details amino acids 284 to 306 (23 residues), see Phobius details amino acids 327 to 357 (31 residues), see Phobius details amino acids 364 to 386 (23 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details amino acids 426 to 444 (19 residues), see Phobius details amino acids 456 to 476 (21 residues), see Phobius details PF11412: DsbD_N" amino acids 53 to 161 (109 residues), 103.7 bits, see alignment E=2.1e-33 PF13386: DsbD_2" amino acids 212 to 409 (198 residues), 34.3 bits, see alignment E=7.2e-12 PF02683: DsbD" amino acids 216 to 416 (201 residues), 65.6 bits, see alignment E=1.9e-21 PF13899: Thioredoxin_7" amino acids 504 to 585 (82 residues), 45.2 bits, see alignment E=2.5e-15 PF13098: Thioredoxin_2" amino acids 514 to 606 (93 residues), 42.3 bits, see alignment E=2.5e-14

Best Hits

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 85% identity to amc:MADE_03921)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (628 amino acids)

>MIT1002_03939 Thiol:disulfide interchange protein DsbD precursor (Alteromonas macleodii MIT1002)
MTLPPFSSGNASASLFQRFTAYVLSAFCLMTLLSTFALAQVPNAFDDPFVDEPQFLDVDQ
AFAFDFNQEDDVLTVSFDIADGYYLYLKQFKFVAKQAEIGEPEYPNGVMIQDEFFGESEV
FYNGVSITLPIESASSDGVVKIRYQGCADAGLCYPPTVKVVYLNEVGSSAVAETDTASEP
NNAATSSQSEQFDLAQRLIDKDNLALTLALFFALGVGLAFTPCVFPMYPIVSGIVIGQGK
PKTASHSFWLTFVYVQGMAITYSLLGLVVAVAGAQFQAALQHPVVLGVFIVLFVALAVAL
FGGFEIQLPAKYQEKLTHMSNNQTPGSFAGVFVMGVLSGLIASPCTTAPLTGILLFIAQT
GDMTLGFISLYLLSIGMGVPLILFGMTGGKLLPKAGNWMNVVKVTFGFMMLAVAIVFIER
LYNSPATGFLWGLLGFGLFGYYWVLNRASKNSLMKLVRAVVVAIGIMGSAGLTYQAGLNT
GLWGEHADGVHAGHPDFVVARDLADLRNKIAAANTKGKTVMVDLYADWCVACKEFEKYTF
PDEKVVSALSNTVWMQMDLTDNTPERQEIFDTFTVLGLPTILFFDENGDELTKARVTGFM
KADAFAGHVNEWLNNGSNTNDGQSGRLD