Protein Info for MIT1002_03499 in Alteromonas macleodii MIT1002

Annotation: Nucleoside permease NupX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 403 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 30 to 46 (17 residues), see Phobius details amino acids 58 to 76 (19 residues), see Phobius details amino acids 83 to 106 (24 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 191 to 211 (21 residues), see Phobius details amino acids 250 to 274 (25 residues), see Phobius details amino acids 341 to 365 (25 residues), see Phobius details amino acids 378 to 400 (23 residues), see Phobius details TIGR00804: nucleoside transporter, NupC family" amino acids 1 to 399 (399 residues), 489.5 bits, see alignment E=4.2e-151 PF01773: Nucleos_tra2_N" amino acids 5 to 77 (73 residues), 80.9 bits, see alignment E=1.2e-26 PF07670: Gate" amino acids 89 to 186 (98 residues), 70.8 bits, see alignment E=1.8e-23 PF07662: Nucleos_tra2_C" amino acids 191 to 397 (207 residues), 266 bits, see alignment E=3.7e-83

Best Hits

Swiss-Prot: 60% identical to Y519_HAEIN: Uncharacterized transporter HI_0519 (HI_0519) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K03317, concentrative nucleoside transporter, CNT family (inferred from 97% identity to amc:MADE_00729)

MetaCyc: 46% identical to putative nucleoside transporter (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Nucleoside permease NupC" in subsystem Deoxyribose and Deoxynucleoside Catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (403 amino acids)

>MIT1002_03499 Nucleoside permease NupX (Alteromonas macleodii MIT1002)
MVSLLGIAVLLGIAFALSSAKRNINWRTVGGAFAIQASVGAFVLYSEPGKEVLLSATRFV
ANIIAYSQEGINFLFGPIGDKSIAFIFAFNVLPVIVFFSALIAVLYHLKVMGLIIKVIGG
FLQKALGTSRPESMSSAANIFVGQTEAPLVVRPFIPHMTSSELFAIMVGGLASIAGSVMA
GYAGMGVDLKYLLAASFMAAPGGLLMAKIMLPETSKPNEDLHDVDAEDTGYANVFDAAAS
GAASGMQLALNVGAMLLAFIALIAMFNGLIGWTAGLFGYENVTFEGILGYVLQPLAWAIG
VPWEEAQLAGSFIGQKMVVNEFVAYLNFLENQSQLSEASQAIITFALCGFANFSSIAILM
GGIGAMAPTRRKEIARLGLKAVIAATLSNLMSAALAGFYLSLG