Protein Info for MIT1002_03444 in Alteromonas macleodii MIT1002

Annotation: Prolyl tripeptidyl peptidase precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 727 PF00930: DPPIV_N" amino acids 113 to 435 (323 residues), 336.9 bits, see alignment E=4.6e-104 PF02129: Peptidase_S15" amino acids 481 to 641 (161 residues), 35 bits, see alignment E=5.2e-12 PF01738: DLH" amino acids 517 to 705 (189 residues), 23.6 bits, see alignment E=1.4e-08 PF00326: Peptidase_S9" amino acids 531 to 726 (196 residues), 189 bits, see alignment E=3.2e-59

Best Hits

Swiss-Prot: 50% identical to DAP4_PSEMX: Dipeptidyl aminopeptidase 4 (dap4) from Pseudoxanthomonas mexicana

KEGG orthology group: K01278, dipeptidyl-peptidase 4 [EC: 3.4.14.5] (inferred from 96% identity to amc:MADE_00782)

Predicted SEED Role

"Dipeptidyl peptidase IV"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.14.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (727 amino acids)

>MIT1002_03444 Prolyl tripeptidyl peptidase precursor (Alteromonas macleodii MIT1002)
MLSTALNAETLTIERIFSSPSLDGNAPRSLKVSPDGQRVTFLKGKQTDYERLDLWEYHIE
SGQTRMLFDSNDLQSGEEVLSDEEKARRERMRLSGSGIVSYQWSDDGKALLFPLGGDVFY
HKLGEKGAKQLLDTDAFETDIKLSPKGNYISFIRDQNLYVKHIESGKETAITKEGGDNIK
FGMAEFVAQEEMGRMTGYWWSPDETKIAFTKVDESPVDVITRSEIYADDIKLIEQKYPKA
GTPNVLVELAIQDINSGDRTWVDLGEDKDIYFARGKWMPNNTTFTYQWQTRDQQTLELRA
FDLNSKKENVLLSESSNTWVNLHNDLYFLKDKGQFIWASERDGFKHLYLFDNKGKLVKQL
TKGDWVVDSVEAIDTANNRLYFSGRKDTPLESHVYSVPLDGGEISRITELGAYHSAAFSK
DASIFIDRFSTINSPAQVSLNSATGERITWLEENKVEEGHPLHAYMDSWTAPEFGDITTK
DGATLKYRIYTPDSAKQNPKQKHPVIVYLYGGPHAQVVTNSWAGNRGLLFQHWVDQGYVV
FTLDNRGSNYRGKGFEDPIYKKMGFIEVDDQVAGVEFLRTLDYVDAERIGVHGHSYGGYM
TLMTMFKAGDYFAAGVSGAPVTDWRLYDTHYTERYMGNPNTDDDAYTASSVFPYAKDLKG
DLLIYHGMADDNVLFTHSTMLYKHLQDLAIPFETMDYPGKKHSIRGKQTGIHLYKTITNF
FNRNLKD