Protein Info for MIT1002_03379 in Alteromonas macleodii MIT1002

Annotation: Sulfite reductase [NADPH] hemoprotein beta-component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02041: sulfite reductase (NADPH) hemoprotein, beta-component
  • amino acids 18 to 560 (543 residues), 924.5 bits, E=9.2e-283
• PF03460: NIR_SIR_ferr
  • amino acids 78 to 138 (61 residues), 51.9 bits, E=5.1e-18
  • amino acids 354 to 418 (65 residues), 43.5 bits, E=2.2e-15
• PF01077: NIR_SIR
  • amino acids 172 to 330 (159 residues), 144.3 bits, E=2.3e-46

Best Hits

Swiss-Prot: 97% identical to CYSI_ALTMD: Sulfite reductase [NADPH] hemoprotein beta-component (cysI) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 97% identity to amc:MADE_03588)

MetaCyc: 72% identical to sulfite reductase, hemoprotein subunit (Escherichia coli K-12 substr. MG1655)
Sulfite reductase (NADPH). [EC: 1.8.1.2]

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (12/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Protein Sequence (573 amino acids)

>MIT1002_03379 Sulfite reductase [NADPH] hemoprotein beta-component (Alteromonas macleodii MIT1002)
MSNEKSPFIVEGKLADNERLKRESNNLRGTITTDLKDDLTGGFTADNFQLIRFHGMYQQD
DRDIRAERAKQKLEPLHNVMLRARLPGGVITPDQWLAIDKFAADHTMYGSIRLTTRQTFQ
FHGVLKPKIKSMHQMLNKVGIDSIATAGDVNRNVLCTSNPVESELHLQAFEWAKKISEHL
LPKTRAYAEIWLDGEKVETTEKPVEPILGDNYLPRKFKTTVVIPPQNDVDVHANDLNFVA
IAENGQLVGFNVLVGGGLAMTHGDKSTYPRKASDFGFIPLENTLDVAAAVVTTQRDWGNR
VNRKNAKTKYTLERVGVDNFKAEVEKRAGVTFQDSRAYEFTGRGDRFGWVEGIDGKYHLT
VFIENGRILDYPGKTLKTGCAEIAKIHKGDFRLTANQNLIIAGVAPQDKDKIEALAREHG
LIAPSISNQRLDSMACVALPTCPLAMAEAERYLPDAVTELEGLLAKHGLEEDSVIFRVTG
CPNGCGRAMLSEVGLVGKGPGKYNLHLGGNREGTRIPRMYRENISEQEIMAELDSLFGQW
AKDREAGEAFGDYVVRAGVVKPVVDSARDFYDE