Protein Info for MIT1002_03371 in Alteromonas macleodii MIT1002

Annotation: HTH-type transcriptional repressor FabR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 198 PF00440: TetR_N" amino acids 14 to 57 (44 residues), 34.5 bits, see alignment 1.4e-12 PF21943: TetR_C_46" amino acids 85 to 188 (104 residues), 27.4 bits, see alignment E=3.3e-10

Best Hits

Swiss-Prot: 63% identical to FABR_KLEP7: HTH-type transcriptional repressor FabR (fabR) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: None (inferred from 98% identity to amc:MADE_03580)

Predicted SEED Role

"Unsaturated fatty acid biosythesis repressor FabR, TetR family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (198 amino acids)

>MIT1002_03371 HTH-type transcriptional repressor FabR (Alteromonas macleodii MIT1002)
MSRQEQKLKTRQNIIHAAFSLLDENRSLSAISLREVAREAGIAPTSFYRHFKDMDELGLT
LVDEAGLALRQLMRQARRRIASGGGVIHTSVETFMEFIAANTNVFRLLLREHTGTSSAYR
LAVFREIQHFIDELTDYIIEQQGVEYACAQLQADAMVRLVFSAGAEALEADDKLRREIGE
RVKAQLRFVQLGATQKSV