Protein Info for MIT1002_03065 in Alteromonas macleodii MIT1002

Annotation: 2,4-dienoyl-CoA reductase [NADPH]

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 696 PF00724: Oxidored_FMN" amino acids 31 to 352 (322 residues), 272.2 bits, see alignment E=3e-84 PF07992: Pyr_redox_2" amino acids 401 to 673 (273 residues), 95.6 bits, see alignment E=1.6e-30 PF03486: HI0933_like" amino acids 401 to 438 (38 residues), 23.9 bits, see alignment 6.9e-09 PF13450: NAD_binding_8" amino acids 404 to 445 (42 residues), 35.4 bits, see alignment 4.2e-12

Best Hits

KEGG orthology group: K00219, 2,4-dienoyl-CoA reductase (NADPH2) [EC: 1.3.1.34] (inferred from 94% identity to amc:MADE_03303)

Predicted SEED Role

"2,4-dienoyl-CoA reductase [NADPH] (EC 1.3.1.34)" (EC 1.3.1.34)

Isozymes

Compare fitness of predicted isozymes for: 1.3.1.34

Use Curated BLAST to search for 1.3.1.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (696 amino acids)

>MIT1002_03065 2,4-dienoyl-CoA reductase [NADPH] (Alteromonas macleodii MIT1002)
MNTPSSQTVSQTAIPQSAHNSEQLSPYFPNLLAPLDLGFTQLRNRTLMGSMHLGLEEEKG
GFDKLAAFYAERAKGGAGLIVTGGISPNISGWVAPFAGRMTRSRHAKKHRVITDAVHKED
GKICMQILHSGRYGYHPLAVSASPMKSPITPFKPRELSSRGVRSTIKDYVKCASLAQKAG
YDGVEIMGSEGYLINQFFCERTNHRNDEWGGSLENRARLAIEIVKGVREKVGTNFIIIYR
LSMLDLVEGGAKWEEVVYLAKEIEKAGATLINTGIGWHEARVPTISTSVPRAAFTWITER
MKKEVSIPLITTNRINTPEVAESVLAQGHADMVSMARPFLADAHFVAKAMRNESKLINTC
IACNQACLDHAFEQKRASCLVNPQACYETELSFTPTQNKKKLAVVGAGPAGLAFSMYAAE
RGHEVHLFDKASEIGGQFNYAKQVPGKEEFYETLRYFDNQLARLGVTVHLNTQVNVESLS
NKGFDEVVLATGINPRTLTIDGHDHPKVMSYLDVLRDHKPVGKKVAIVGAGGIGFDVAEF
LVEHEHLAKDKEKWLAHWGIDKDYAAPGALKEKAIEPSDREVYLLQRKTSKVGKGLGKTT
GWIHRQSLKHHNVQLINGVSYKKVDDEGLHVLINDTPKVLPVDNVIVCAGQEPFKPLQQP
LEEAGFTVHIIGGADVAAELDAKRAIRQGAELAARI