Protein Info for MIT1002_02759 in Alteromonas macleodii MIT1002

Annotation: ATP-dependent Clp protease ATP-binding subunit ClpX

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 TIGR00382: ATP-dependent Clp protease, ATP-binding subunit ClpX" amino acids 10 to 413 (404 residues), 701.9 bits, see alignment E=1.4e-215 PF06689: zf-C4_ClpX" amino acids 15 to 51 (37 residues), 72.1 bits, see alignment 1.1e-23 PF01078: Mg_chelatase" amino acids 111 to 147 (37 residues), 21.5 bits, see alignment 5.4e-08 PF07724: AAA_2" amino acids 113 to 311 (199 residues), 119.4 bits, see alignment E=6.7e-38 PF07728: AAA_5" amino acids 115 to 192 (78 residues), 25.7 bits, see alignment E=4.1e-09 PF00004: AAA" amino acids 116 to 233 (118 residues), 58.2 bits, see alignment E=5e-19 PF10431: ClpB_D2-small" amino acids 318 to 395 (78 residues), 48.9 bits, see alignment E=2.1e-16

Best Hits

Swiss-Prot: 90% identical to CLPX_PSEA6: ATP-dependent Clp protease ATP-binding subunit ClpX (clpX) from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

KEGG orthology group: K03544, ATP-dependent Clp protease ATP-binding subunit ClpX (inferred from 95% identity to alt:ambt_04065)

MetaCyc: 84% identical to ATP-dependent Clp protease ATP-binding subunit ClpX (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"ATP-dependent Clp protease ATP-binding subunit ClpX" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (424 amino acids)

>MIT1002_02759 ATP-dependent Clp protease ATP-binding subunit ClpX (Alteromonas macleodii MIT1002)
MSDKQSGDGDNKLLYCSFCGKSQHEVRKLIAGPSVFICDECVELCNDIIREEIKEIAPKQ
KQDALPKPSEIHAHLDDYVIGQEHAKKVLSVAVYNHYKRLRNGDVHEGVELGKSNILLIG
PTGSGKTLLAETLARLLDVPFTMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQRG
IVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVD
TSKILFICGGAFAGLDKVIEQRAQKDTGIGFGATVKSKDNSKQISELFKQVEPEDLVKYG
LIPEFIGRLPVVTSLEELNEEALIQILREPKNAITKQYGALFSMEDVELEFRDDALNAIA
KKAMDRKTGARGLRSIVEAVLLDTMYDLPSMEDVSKVVIDETVIRGESKPILIYDSNEKK
AASE