Protein Info for MIT1002_02753 in Alteromonas macleodii MIT1002

Annotation: Succinyl-diaminopimelate desuccinylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01246: succinyl-diaminopimelate desuccinylase
  • amino acids 17 to 386 (370 residues), 395.3 bits, E=1.3e-122
• PF01546: Peptidase_M20
  • amino acids 72 to 386 (315 residues), 129.6 bits, E=1.6e-41
• PF07687: M20_dimer
  • amino acids 185 to 287 (103 residues), 77.3 bits, E=8.1e-26

Best Hits

Swiss-Prot: 83% identical to DAPE1_ALTMD: Succinyl-diaminopimelate desuccinylase 1 (dapE1) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: None (inferred from 83% identity to amc:MADE_02089)

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate desuccinylase (EC 3.5.1.18)" in subsystem Arginine Biosynthesis extended or Lysine Biosynthesis DAP Pathway (EC 3.5.1.18)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.5.1.18

Use Curated BLAST to search for 3.5.1.18

Protein Sequence (391 amino acids)

>MIT1002_02753 Succinyl-diaminopimelate desuccinylase (Alteromonas macleodii MIT1002)
MSIQPLPSIAPARSIYFAEVLMARASITPQDAGCQSYLIYKLEKLGFFCEKYTINGVSNL
VARWGQGPNHFAFSGHTDVVPPGPLDRWKSPPFSPVISKNKLYGRGAADMKTGIAAMLAA
TERTIASLDKEKVSFWWLITSDEEGEAEWGSKWIAEYLASKNVQLDMCLVGEPSASASTG
DTIKIGRRGSLSGTIHIAGKQGHVAYPKTAVNAIHKASNVINALTQYPFDKGSDDFPGTT
LQITHMDTGSFTDNIVPSAVRIEFNVRYSWQFNQNSLSVLLRSIINSIDTEAKVSFSRPC
EAYLSKPKSNAEHCLIACVEKAIKGATGRYPVISTSGGTSDGRFFASEHTQVVEVGVPNT
TIHQINEHIHVSDLLTLEDIYTDILKYVGER