Protein Info for MIT1002_02742 in Alteromonas macleodii MIT1002

Annotation: Isoleucine--tRNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 939 TIGR00392: isoleucine--tRNA ligase" amino acids 15 to 843 (829 residues), 958.4 bits, see alignment E=1.9e-292 PF00133: tRNA-synt_1" amino acids 27 to 643 (617 residues), 493.5 bits, see alignment E=1.4e-151 PF09334: tRNA-synt_1g" amino acids 58 to 201 (144 residues), 40.4 bits, see alignment E=4.8e-14 amino acids 584 to 634 (51 residues), 21.4 bits, see alignment 3e-08 PF13603: tRNA-synt_1_2" amino acids 239 to 362 (124 residues), 28.8 bits, see alignment E=2.5e-10 PF01406: tRNA-synt_1e" amino acids 578 to 651 (74 residues), 28.5 bits, see alignment 3e-10 PF08264: Anticodon_1" amino acids 687 to 842 (156 residues), 97.1 bits, see alignment E=2.9e-31 PF06827: zf-FPG_IleRS" amino acids 899 to 927 (29 residues), 34.5 bits, see alignment (E = 4.3e-12)

Best Hits

Swiss-Prot: 65% identical to SYI_ALIF1: Isoleucine--tRNA ligase (ileS) from Aliivibrio fischeri (strain ATCC 700601 / ES114)

KEGG orthology group: K01870, isoleucyl-tRNA synthetase [EC: 6.1.1.5] (inferred from 95% identity to amc:MADE_03030)

Predicted SEED Role

"Isoleucyl-tRNA synthetase (EC 6.1.1.5)" (EC 6.1.1.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.1.1.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (939 amino acids)

>MIT1002_02742 Isoleucine--tRNA ligase (Alteromonas macleodii MIT1002)
MSDYKATLNLPETAFPMRGNLAQREPKMLKDWQEKGVYSKIREAKKGKKPFILHDGPPYA
NGDIHIGHAVNKILKDIIVKSKNLSDFDSPYVPGWDCHGLPIELMVEKKVGKPGKKVTAA
EFRQKCREYAQKQIDGQMADFKRLGVFGEWDNPYKTMDFKSEADIIRALSKIVDSGHLEK
GFKPVHWCTDCGSALAEAEVEYKDKVSPAIDVKFPVADVAAIAEAFGVSEGDLTSHKAGV
VIWTTTPWTLPANRAISLHPELTYAIVEVQPSNEWLVVAQDLLESCMSRYGVEEFREVAT
CTGAALDKLKVNHPFLDLEVPLILGDHVTTDSGTGCVHTAPAHGVDDFNVGKQYDIEVYN
PVGNNGVYLENTPLFAGQFVFKANDEIIETVKEKGNLVLNVKYEHSYPHCWRHKTPIIFR
ATPQWFVSMDKKGLRAESLEQIKQTKWIPDWGQNRIEKMVEGRPDWCISRQRTWGVPIPL
YVHKLTGEIHPESAALMEKVAQEVEAKGIQAWWDLDDAALLGSELDNYEKVTDTLDVWFD
SGVTHYFVVDRRDDIPASADLYLEGSDQHRGWFMSSLMSSTAMHGHAPYKEVLTHGFTVD
AHGRKMSKSVGNVVAPQEVTNKLGADILRLWVASTDYRGEIAVSDEILKRAADGYRRVRN
TARFLLANLNGFSVEDAVAEEDMVALDRWIVARAKALQEELIEAYDNYDLLVVSQKLTHF
CSIELGSFYLDVIKDRQYTAKADGLARRSCQTAMYHIIEALVRWMAPITSFTAQEIWETL
PGERSEFVFTETWYEGFNNFTQSDTFNDALWHQVLSVKDAANQAMEQARKDGELGGSLEA
SISLYATESLYNVLAKLEDELRFVLITSGVTLTKVDSAPSDAKATDVEGLWLSVDKASGE
KCVRCWHHREDVGSHEGHEELCGRCVTNIDGDGEERHYA