Protein Info for MIT1002_02632 in Alteromonas macleodii MIT1002

Annotation: ATP phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 TIGR00070: ATP phosphoribosyltransferase" amino acids 7 to 196 (190 residues), 183.7 bits, see alignment E=3.2e-58 PF01634: HisG" amino acids 54 to 215 (162 residues), 162.7 bits, see alignment E=7e-52 TIGR03455: ATP phosphoribosyltransferase, C-terminal domain" amino acids 202 to 299 (98 residues), 93.7 bits, see alignment E=6.4e-31 PF08029: HisG_C" amino acids 224 to 297 (74 residues), 81.9 bits, see alignment E=2.9e-27

Best Hits

Swiss-Prot: 68% identical to HIS1_TOLAT: ATP phosphoribosyltransferase (hisG) from Tolumonas auensis (strain DSM 9187 / TA4)

KEGG orthology group: K00765, ATP phosphoribosyltransferase [EC: 2.4.2.17] (inferred from 99% identity to amc:MADE_01118)

MetaCyc: 65% identical to ATP phosphoribosyltransferase (Escherichia coli K-12 substr. MG1655)
ATP phosphoribosyltransferase. [EC: 2.4.2.17]

Predicted SEED Role

"ATP phosphoribosyltransferase (EC 2.4.2.17)" in subsystem Histidine Biosynthesis (EC 2.4.2.17)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.17

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (300 amino acids)

>MIT1002_02632 ATP phosphoribosyltransferase (Alteromonas macleodii MIT1002)
MSNSKRLRIAVQKSGRLSDDSIALLKAIGIKLNIRDRLLIAHSTNQPIDLLRVRDDDIPG
LVMDGVVDLGFIGENELEEKMLERKAAGKPFEYEVLRRLDYGGCRLSIAVPNEMDYQGIQ
SLEGKKVATTYPYLLERYFKEQGINAKAVMLQGSVEVAPRAGVADAICDLVSTGATLEAN
GLVEKDVIFRSKAVLIKRADGELSDEKETLVNRLMPRVDGVLLAKESKYIMLHAPKAYLE
QVKSLLPGAENPTVLPLAGNEEQVAIHVVSTETLFWETMEKLKALGCSSILVMPIEKMMG