Protein Info for MIT1002_02584 in Alteromonas macleodii MIT1002

Annotation: Ureidoglycolate lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 PF01557: FAA_hydrolase" amino acids 19 to 219 (201 residues), 169.8 bits, see alignment E=3.5e-54

Best Hits

Swiss-Prot: 54% identical to YCGM_ECOLI: Uncharacterized protein YcgM (ycgM) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 82% identity to amc:MADE_01142)

MetaCyc: 35% identical to 3-fumarylpyruvate hydrolase (Bradyrhizobium sp. JS329)
RXN-10445 [EC: 3.7.1.20]

Predicted SEED Role

"FIG094199: Fumarylacetoacetate hydrolase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.7.1.20

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (222 amino acids)

>MIT1002_02584 Ureidoglycolate lyase (Alteromonas macleodii MIT1002)
MAYRHIDSQGNEISLPVSKVVCIGRNYLDHIEEMNSTVSEAPLLFMKPKAALCYMQKPIA
IPTDKGECHNELEVAVLLKSSLKNASVDDVKAAIWGIGLGLDLTLREVQAELKKQGQPWE
RAKSFDNSAPLSGFVPLSEIENLEDLRFTLTINGVVRQQGHTELMLHKIIPLIAHMSSIF
TLDSGDVILTGTPKGVGKLCSQDTIVATLDNHLTVETEVIAE