Protein Info for MIT1002_02564 in Alteromonas macleodii MIT1002

Annotation: clan AA aspartic protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF13975: gag-asp_proteas" amino acids 301 to 393 (93 residues), 58.1 bits, see alignment E=1.1e-19 PF13650: Asp_protease_2" amino acids 304 to 390 (87 residues), 50.1 bits, see alignment E=3.8e-17

Best Hits

KEGG orthology group: None (inferred from 78% identity to amc:MADE_01167)

Predicted SEED Role

"peptidase A2A, retrovirus, catalytic"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (411 amino acids)

>MIT1002_02564 clan AA aspartic protease (Alteromonas macleodii MIT1002)
MKTWLAIVLSLFLIVSLGINVYLWLSLKQHNDKAYALEASYEHRLDSDKQLETQAQLVDE
TQVNEKAEPFNNERSPANFSPMTGANTAPNELDDLRTSSSLVNQDQLESLTTLLNNEQYA
FLATELTNLLKYDPLNESLLLLEGELIELTKPLSTAIVHYYDLAELPLPTETLSFIDAKI
ATLYQHAQTQLSQDEQWELVARLNEPLYQRIPDARHYTLNLAEAYAYQQKLTLMEDVLAA
LPSIDRDANIIRNKAYEMRDIANADATPNKSEIEPTGAEAARYQTRVALERIGDQYRLDV
KALNQKATMILDTGASTTAISSRLFARLGRMRNLTFIGNFNIRTASGTIEAPLVQIPRFY
FAGYEFNDVSAIVLPEDALPDADGLLGMNVLGQFDFAIMPQSSELILTERD