Protein Info for MIT1002_02462 in Alteromonas macleodii MIT1002

Annotation: Bacteriophytochrome cph2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 627 transmembrane" amino acids 24 to 42 (19 residues), see Phobius details amino acids 49 to 68 (20 residues), see Phobius details amino acids 74 to 97 (24 residues), see Phobius details amino acids 106 to 136 (31 residues), see Phobius details amino acids 149 to 171 (23 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 195 to 359 (165 residues), 133.7 bits, see alignment E=2.7e-43 PF00990: GGDEF" amino acids 199 to 356 (158 residues), 147 bits, see alignment E=4.2e-47 PF00563: EAL" amino acids 376 to 611 (236 residues), 222.4 bits, see alignment E=5.7e-70

Best Hits

KEGG orthology group: None (inferred from 79% identity to amc:MADE_01217)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (627 amino acids)

>MIT1002_02462 Bacteriophytochrome cph2 (Alteromonas macleodii MIT1002)
MQVKDFFSSSAKLADLTSLRRRRVIQISAVTGFGLFASSLVARGITFDIFLLGLFSLIVT
GSLAYKYYVTTSSYLLLGAMSSMLFALSATGAGVFDIAMIGYPGVIIFAALLGGIALFGT
VLSLVLLQCITLTWLIMHDVVTPNPPILSWSHVLFIMVIYVITGFSVFILIQDIRRLMQS
LQQEVSKVEQNRAHIQHLAHHDPLTNLPNRILGERLFNEKLRESEEKGLQLALLFIDLDN
FKPVNDALGHAAGDRFLQKISQTITDHLSTKQSLIRFGGDEFIVLAPEISDKSEIDDLCK
NLITWCSNEFEVLQTKVVVSGSIGVAQAPYDGIKFKQLCRKADIAMYEAKRNGRNRYEYY
DVRFDEENDEKFTLIQRLRPAVQANEFEVYYQPLIDLASNEVQAVEALLRWPQKDGSMIF
PDKFIPLAESSGLIIPLGAWVLNQACEFCAKQHENGHTNLTVAVNLSFAQFKDGTLPAVV
EQALQNSQLAPQFLELELTETILADENGTTGEQLEAIKSLGVHFAIDDFGTGYSNLNYLQ
TFSARKLKIDRIFINTLGIGENDAPLVAAIISIADSLGMKAVAEGIESKPALEKLIKMGC
DLGQGYYWSKPLPAPEIERLLSNHPTK