Protein Info for MIT1002_02453 in Alteromonas macleodii MIT1002

Annotation: Extracellular ribonuclease precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1336 signal peptide" amino acids 1 to 39 (39 residues), see Phobius details PF04231: Endonuclease_1" amino acids 271 to 486 (216 residues), 138.1 bits, see alignment E=6.1e-44 PF00932: LTD" amino acids 524 to 634 (111 residues), 51.7 bits, see alignment E=1.6e-17 PF03372: Exo_endo_phos" amino acids 966 to 1258 (293 residues), 41.9 bits, see alignment E=1.5e-14

Best Hits

KEGG orthology group: K07004, (no description) (inferred from 79% identity to amc:MADE_01224)

Predicted SEED Role

"Extracellular ribonuclease Bsn / Extracellular deoxyribonuclease PA3909 (required for catabolism of external DNA)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1336 amino acids)

>MIT1002_02453 Extracellular ribonuclease precursor (Alteromonas macleodii MIT1002)
MIHEGNTQKYKLRKSAKVVNALLAGALSLGVVSINASADTVWQEDFEANELQGKGATGSD
PAGAIVDLEGVDRWSVDVSASELSATSDWFRVESGAMQARDTDGEVVWLSESIDISGAGD
ITINAVLSQSGNFESTDYIDVFYSLDGGAFELITLSEGATNTVQEDFVSATLTETIGSGS
TLELKVAMANNSGTEYLNLDSISVSGNGTTDGGDTGGHPDNGGEPSNELLFLSGTCFNCP
DLEAVNLASDFVASDYYAALDTAIANGESAQTLKDTAHNIIENGHRTLSYSEVWTALTYT
DEDPANTDNVILFYKGISQGKFTNGSGSQSTNPDNWNREHVWAKSHGFPSSSLTAYSDIL
HLRPTDISVNSSRGNLDFDFSDSALSEAPLNRVDGDSFEPRDAVKGDVARSMLYMDVRYD
GNTAGDTEDDLVLVNRLTSTSEAAFGKLCVLLQWHESDPVDDFERRRNERVYEFQGNRNP
FIDKPELASLIFNESCDGTGGDTGGDTGGDTGGDTGGDTGGDTTPSTSSIYISEYIEGGG
FNKGIELFNSSTQPVSLAGYELVLLSNGETADADRKVLALEGTIPAGGVATFAHGSADAL
LTAGSTISSFVINFNGDDYIELVANGQVVDALGTYGVKTNWGKDVTLVRKSSVTAGNPNR
NPAFTLEEWDSLPKDTLNNFGSHNGSVSEPTDPTDPTDPTDPTDPVGEVVLISAIQGEGD
TSPLTGNDVVIEAVVTKVVPEMNGFFIQEEAADSDGNAATSEGVFAYSTTFTEYPSVGDA
VRVSGAVAEYNGITEIVLSANAETLGAGGDILTTSIEMPFDESVYLESLEGMQVQFQQTL
NVTDVYNLGRYGQFNVSSGRLMIPTNQYAAGSSEAIALAEANARNTLLVDDGSSTQNADD
IPFPVGGLSHANPLRLGDSVEGLEGVIHYAFGAYNLIPVGALQTVRTNPRTDVPQLDVQG
DVKVASFNVLNYFNGPNFPTSRGADSEDEFARQQAKTVAAIVAMDADVLGLVEIENDGYG
SDSAIASLVNSVNAELGSDVYSYVALESLLGGDEIAVGIIYRPATVTPQGAAVTSSEAPF
DYGNRQPLLQTFSVNSNSEAFTLAVNHFKSKGSCGSATGNDADLGDGQGCWNELRTQAAL
GLTALVQNSEGLSDRVIVMGDLNAYAKEDPILALEDAGYSNLVNLFHGESAYSYSFGGEM
GYLDHALSSSTLTEYVADATVWHINADEPRVFDYNVEYKSETQLSSYYGADAYRSSDHDP
VIVVLDFPETSEPEPVIGDFDGDSDIDNTDIVAFYTLLLQRQATVEEHDFNNDGRLNIYD
LYALMSMCTRTACAVQ