Protein Info for MIT1002_02404 in Alteromonas macleodii MIT1002

Annotation: Glucokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00749: glucokinase
  • amino acids 6 to 308 (303 residues), 310.8 bits, E=5.5e-97
• PF02685: Glucokinase
  • amino acids 6 to 313 (308 residues), 370.2 bits, E=3.9e-115

Best Hits

Swiss-Prot: 45% identical to GLK_CITK8: Glucokinase (glk) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K00845, glucokinase [EC: 2.7.1.2] (inferred from 95% identity to amc:MADE_01247)

Predicted SEED Role

"Glucokinase (EC 2.7.1.2)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis (EC 2.7.1.2)

MetaCyc Pathways

• glycolysis III (from glucose) (11/11 steps found)
• homolactic fermentation (11/12 steps found)
• heterolactic fermentation (15/18 steps found)
• glycogen degradation I (7/8 steps found)
• Bifidobacterium shunt (12/15 steps found)
• trehalose degradation II (cytosolic) (2/2 steps found)
• sucrose biosynthesis II (6/8 steps found)
• sucrose degradation III (sucrose invertase) (3/4 steps found)
• GDP-α-D-glucose biosynthesis (2/3 steps found)
• trehalose degradation V (2/3 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• glycogen degradation II (4/6 steps found)
• trehalose degradation I (low osmolarity) (1/2 steps found)
• 1,3-propanediol biosynthesis (engineered) (6/9 steps found)
• chitin biosynthesis (6/9 steps found)
• glucose and glucose-1-phosphate degradation (3/5 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (4/7 steps found)
• trehalose degradation IV (1/3 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Galactose metabolism
• Glycolysis / Gluconeogenesis
• Nucleotide sugars metabolism
• Starch and sucrose metabolism
• Streptomycin biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.2

Protein Sequence (317 amino acids)

>MIT1002_02404 Glucokinase (Alteromonas macleodii MIT1002)
MSQKFVADVGGTNIRVARVTESGVADIKKYMCNDFASIDLAIAQYFSDMPEYSFSQGCIA
IACPVLGDQVEMTNHSWAFSQNALRSQLKLDALFVINDFTAVAHSLPVLGEEQVVQIGEG
TAKENGNIAVFGPGTGLGVEHITMTSTGWQTLDGEGGHVDFAPVDETDVVVWRHLQSTLG
RASAEEVMSGRGLHNIYTALANQASTPVVFTEPAQITDAALNGTCKIAEATLTQFCRIMG
SFAGNLALNMATTGGIFIGGGIANRFPEFIQNSDFRARFEAKGQMKHYVKDIPTYLIAEP
DHGLLGAAAYLNQNTAS