Protein Info for MIT1002_01948 in Alteromonas macleodii MIT1002

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF16078: 2-oxogl_dehyd_N
  • amino acids 12 to 50 (39 residues), 64.7 bits, see alignment (E = 8.6e-22)
• TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component
  • amino acids 15 to 935 (921 residues), 1413 bits, E=0
• PF00676: E1_dh
  • amino acids 224 to 522 (299 residues), 165 bits, E=4.2e-52
• PF02779: Transket_pyr
  • amino acids 597 to 789 (193 residues), 170.9 bits, E=4.4e-54
• PF16870: OxoGdeHyase_C
  • amino acids 794 to 936 (143 residues), 181.6 bits, E=1.6e-57

Best Hits

Swiss-Prot: 71% identical to ODO1_ECOLI: 2-oxoglutarate dehydrogenase E1 component (sucA) from Escherichia coli (strain K12)

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 99% identity to amc:MADE_01875)

MetaCyc: 71% identical to subunit of E1(0) component of 2-oxoglutarate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Oxoglutarate dehydrogenase (succinyl-transferring). [EC: 1.2.1.105, 1.2.4.2]

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (23/26 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (19/22 steps found)
• TCA cycle III (animals) (9/10 steps found)
• TCA cycle II (plants and fungi) (8/9 steps found)
• superpathway of glyoxylate bypass and TCA (10/12 steps found)
• 2-oxoglutarate decarboxylation to succinyl-CoA (3/3 steps found)
• TCA cycle I (prokaryotic) (8/10 steps found)
• TCA cycle VIII (Chlamydia) (5/6 steps found)
• 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA (1/5 steps found)
• L-tryptophan degradation III (eukaryotic) (6/15 steps found)
• L-tryptophan degradation XI (mammalian, via kynurenine) (7/23 steps found)
• superpathway of L-lysine degradation (7/43 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Citrate cycle (TCA cycle)
• Lysine degradation
• Tryptophan metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.105 or 1.2.4.2

Protein Sequence (939 amino acids)

>MIT1002_01948 2-oxoglutarate dehydrogenase E1 component (Alteromonas macleodii MIT1002)
MQESVMKAWWDSSHMAGANAAYVEELYETYLEDPQSVSENWRQIFDNLPKVDGVELETNH
TTIKNQFRQLAALGPTARMSSPSVPSASVSDDRQVKVLQLINAFRFRGHQHANLDPLGLW
KQERVRDLELSHHSLSEQDFDTVFNVGSYAIGKDSMPLGELFKSLNRTYCGSIGAEYMHI
TDTEQKRWLQQKIESVQAKPEISRDEKLGILKGLTAADGMEKYLGSKFPGAKRFSLEGGD
ALIPMLKGLITKAGTAGTKEVVIGMAHRGRLNVLVNVLGKNPSVLFDEFSGKHDDSLGAG
DVKYHAGFSSDFATPGGNVHLALAFNPSHLEIVNPVVMGSVRARLARRNDDTNTVLPITI
HGDSAIAGQGVVQETFNMSQTRGFAVGGTVRIVVNNQVGFTTSKTEDTRSTQYCTDIAKM
VQAPIFHVNSDDPEAVAFVTQLALEYRNKFKKDVVIDLVCYRRHGHNEADEPNATQPLMY
QKIKKHPVPRVIYADQLIAEGVIEQRDADRYVEEYREALDHGACVVEEWRPMTEHSVDWS
PYLGHDWDTPYDGALSVEKLKELGESITTIPEEHKLQSRVNKLYQDRKAMVAGEKLLDWG
MAENLAYATIVDAGEDIRITGQDSGRGTFFHRHAVLHNQKDASTYMPLQHIREGQGEIEI
YDSVLSEEAVMAFEYGYATAEPTCLTIWEAQFGDFANGAQVVFDQFLSSGEAKWGRLCGL
TVLLPHGYEGQGPEHSSARLERFLQMCADHNWQVCVPSTPAQVYNMLRRQVVRPMRKPLI
VMSPKSLLRHPMAVSSLEELAEGKFHNVIGEIDDIDPKNVKRVVMCSGKVYYDLLDQRRK
NEQTDVAIIRLEQLYPFPQEECAKVVAQYSHVKDWVWCQEEPQNQGAWYCSQHHFWQAIP
DGAKLTYAGRDASSSPAVGYVSVHNQQQKALVENALTIK