Protein Info for MIT1002_01800 in Alteromonas macleodii MIT1002

Annotation: Ferric hydroxamate uptake

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 731 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF07715: Plug" amino acids 54 to 156 (103 residues), 56.8 bits, see alignment E=2.9e-19 TIGR01783: TonB-dependent siderophore receptor" amino acids 57 to 731 (675 residues), 282.1 bits, see alignment E=5.4e-88 PF00593: TonB_dep_Rec_b-barrel" amino acids 229 to 700 (472 residues), 196.9 bits, see alignment E=1.2e-61

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 82% identity to alt:ambt_08820)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (731 amino acids)

>MIT1002_01800 Ferric hydroxamate uptake (Alteromonas macleodii MIT1002)
MKTSWVKSTLALSIATLLNAPANAQNTDIQSEADVEKITVHAMHRAYQGAFEYKEVPAAA
QDIDLGLINDAGAINLNDALDLSASVARQNNFGGLWNSFAIRGFSGDENLPSGFLVNGFN
AGRGFGGPRDLSGIDHVEVLKGPKAALFGRGEPGGAVNLVTKRPQFRQGGEIKATYGSWS
QKRIEADVQSVAGSTENVGVRLVGFYEDAESFRDTVETERFGFYPSVTWEASADTTVTYE
LEYTEQKIPFDRGVVAIDGKLGHQPIETFTGDPNGDTIDTEVVGHQIEISHKLADEWNLL
LGAGLRDTTFEGNALENNFGGRQTLFIDPNQALLSRFKRYRNFQTDYFVLRGEIAGQFDT
GSLSHRVIIGADYDKFENDQIILRYRPPFFSSDTDINDLDLEQYLVVDIFNPDYSPLPDV
ELSDNLDRFEVQEAWGIYFQDQINITDNFQVRLGGRFDKFEQEIDNRLASPVSTTSQDDT
RFSPQVGAVYLFDDTTSVYATYGEGFRQLTGSDFAGNPFEPNESKSAEIGVKADLTSMFN
NIRGDITFAVFNIEQSNILVYDDSPEASDGFFLTPAGEARSRGVELDINAEFENDISLWV
SYTFVDAESTNDAADANFVAAIESGDPLINVPENQLSIQLSKGLIFADMPVRIGSGLLYV
DERLGQTATDFYLPSYTTVRAFAEIEPVENLSVKVAVDNLFDEEFYTNSFADVWVEPGAP
QRFRLTAAYRF