Protein Info for MIT1002_01770 in Alteromonas macleodii MIT1002

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 PF08529: NusA_N" amino acids 4 to 127 (124 residues), 118.3 bits, see alignment E=4.5e-38 TIGR01953: transcription termination factor NusA" amino acids 5 to 345 (341 residues), 409.8 bits, see alignment E=8e-127 PF00575: S1" amino acids 135 to 196 (62 residues), 26.3 bits, see alignment E=1.6e-09 PF13184: KH_5" amino acids 233 to 300 (68 residues), 97.2 bits, see alignment E=9.6e-32 TIGR01954: transcription termination factor NusA, C-terminal duplication" amino acids 368 to 417 (50 residues), 73.3 bits, see alignment 1.3e-24 amino acids 443 to 491 (49 residues), 52.4 bits, see alignment 4.2e-18 PF14520: HHH_5" amino acids 435 to 489 (55 residues), 29.7 bits, see alignment 1.4e-10

Best Hits

Swiss-Prot: 71% identical to NUSA_ECO57: Transcription termination/antitermination protein NusA (nusA) from Escherichia coli O157:H7

KEGG orthology group: K02600, N utilization substance protein A (inferred from 99% identity to amc:MADE_01759)

Predicted SEED Role

"Transcription termination protein NusA" in subsystem NusA-TFII Cluster or Transcription factors bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (498 amino acids)

>MIT1002_01770 hypothetical protein (Alteromonas macleodii MIT1002)
MNKEILLVAEAVSNEKQVPREKIFEALEFAIASATKKKNEGEIEVRVSIDRTSGDFDTFR
RWLVIPDDQEQENPFAEITISAAQIDEPEIQLGDYVEEQIESIKFDRITTQTAKQVIVQK
VREAERQQMIAEYEDKVGELVTGTVKKVNRDNIIIDLGNNAEGVIYRDDMLPRETFRPGD
RVRGLLYVIRPEARGAQLFISRTHPDMLVELFRLEVPEIAEETLEIKSAARDPGSRAKIA
VKTNDKRLDPVGACVGMRGSRVQAVSGELGGERVDIVLWDENPAQFVINAMAPAEVASIV
VDEDSNSMDVAVEADNLAQAIGRSGQNVRLASQLTGWELNVMTVEDLNKKHEEENAKVLD
LFTAGLDIDEEFASVLVDEGFTTLEEVAYVPASELLAVEGLDEEMVEELRNRARAFLTTR
ALANEESLEGAEPTEALLNLEGMSKHVAYVLASRGVTDLEELAEQGTDDISDIDELDEEK
AGALIMAARNIVWFSEEE