Protein Info for MIT1002_01646 in Alteromonas macleodii MIT1002

Annotation: Transcription-repair-coupling factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1165 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details PF17757: UvrB_inter" amino acids 139 to 228 (90 residues), 95.3 bits, see alignment 7e-31 TIGR00580: transcription-repair coupling factor" amino acids 156 to 1096 (941 residues), 1112.9 bits, see alignment E=0 PF21132: MFD_D3" amino acids 396 to 466 (71 residues), 58.8 bits, see alignment 1.5e-19 PF02559: CarD_TRCF_RID" amino acids 495 to 550 (56 residues), 68.6 bits, see alignment 1.4e-22 PF04851: ResIII" amino acids 620 to 776 (157 residues), 49 bits, see alignment E=2.4e-16 PF00270: DEAD" amino acids 620 to 782 (163 residues), 102.7 bits, see alignment E=6.4e-33 PF00271: Helicase_C" amino acids 820 to 924 (105 residues), 63.1 bits, see alignment E=9.5e-21 PF03461: TRCF" amino acids 1024 to 1115 (92 residues), 102.1 bits, see alignment E=6.1e-33

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 97% identity to amc:MADE_02437)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1165 amino acids)

>MIT1002_01646 Transcription-repair-coupling factor (Alteromonas macleodii MIT1002)
MTATLLSLPLPAPKKEASSQDHKHWGQLQGSSAALCISQALSQYKGPIVLITADTPSAMK
LEKEIAFFLSDNTKHTPITLFPDWETLPYDSFSPHQDIVSQRLETLFRFTQQGEGIFIVP
VNTLMQRLAPTDYLAKYLLMLNKGDTLDRDQFRRNLEQAGYLHVSQVMSHSEFSVRGSII
DLFPMGSDQPFRIDLFDDEIDSIRYFDTETQRSGEAVNEIRLLPAREFPTDKEAITLFRQ
QFLEKFDANNASESVFSQVSKGTMPSGVEYYLPLFFEKTATLFDYLHPKSLLLLHGDVQD
ASEFFWADVQERYEQYRYNLARPLLAPDELFLPINELFGAIKQWPRASLSSKVLEEKSGT
SNLQCEKLDDIAINSQKKVPAERLIKTVNQATDNGAKVLFCAETQGRREGLLTVLAKAGI
KPKIVDSFSDFIASHDNIGITVGMVDNSFRWQTQEGELLFITETELLGQKVSQRRLRDKR
TATDESAIIRNLAELSIGQPVVHLDHGVGRYLGLQTLDAGGVATEYLCIEYAKQSKLYVP
VASLHLISRYTGGDADSAPVSALGSDAWTKAKQKAAEKVRDVAAELLDVYARRAAKPGFA
YKINWDDYQAFSDSFPFEETPDQAQAIAAVMHDMGSPSAMDRLVCGDVGFGKTEVAMRAA
FLAANAGKQVAILVPTTLLAQQHYENFKDRFAAWPFEIEVMSRFVSGKAQKSVVERIGEG
KVDIVVGTHKLLSSDINYKDLGLVIIDEEHRFGVRQKEKLKSLRADVDILTLTATPIPRT
LNMALSGMRDLSIIATAPARRLSIKTFVQQRNKAVIREAIMREILRGGQVYFLHNEVDSI
ARTAEEIAEIVPEARIAVGHGQMRERELEGVMSDFYHQRYNVLVCTTIIETGIDVPSANT
IIMDRADHLGLAQLHQLRGRVGRSHHQAYAYLLTPHPKRMTKDAVKRLEAISQLEDLGAG
FALATHDLEIRGAGELLGDDQSGQIASIGFSLYMDMLDKAVNALKEGREPSLDDATSGHT
EVELRIPALLPEDYIADVNTRLSLYKRLASCTSQDDIDEFQVECIDRFGLLPEPAKNLIE
VAEIKLKAQALGILKVDLSAQGGTIEFKETTKVNPGYIISLVQTKPNTFKFEGSQKLRLV
KKTETAKERIAFISDIIADFAKESR