Protein Info for MIT1002_01563 in Alteromonas macleodii MIT1002

Annotation: K(+)/H(+) antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 641 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 47 (18 residues), see Phobius details amino acids 53 to 73 (21 residues), see Phobius details amino acids 85 to 107 (23 residues), see Phobius details amino acids 113 to 130 (18 residues), see Phobius details amino acids 150 to 170 (21 residues), see Phobius details amino acids 197 to 219 (23 residues), see Phobius details amino acids 231 to 251 (21 residues), see Phobius details amino acids 256 to 275 (20 residues), see Phobius details amino acids 287 to 306 (20 residues), see Phobius details amino acids 312 to 335 (24 residues), see Phobius details amino acids 343 to 364 (22 residues), see Phobius details amino acids 374 to 395 (22 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 10 to 389 (380 residues), 193.1 bits, see alignment E=7.3e-61 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 12 to 302 (291 residues), 247.7 bits, see alignment E=7.8e-78 PF02254: TrkA_N" amino acids 421 to 535 (115 residues), 87.5 bits, see alignment E=8.5e-29

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 90% identity to amc:MADE_02528)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (641 amino acids)

>MIT1002_01563 K(+)/H(+) antiporter (Alteromonas macleodii MIT1002)
MTGYFLYAFIYLVAAVIAVPIAKRLGLGSVLGYLIAGLVIGPIFGLVGDETVAIQHFAEF
GVVMMLFLVGLELEPRSLWAMKSKLMGLGGLQLALTTALITGVAILLDQPFSIALTIGLI
FALSSTAIVLQTLQEKGLQKTEGGKSAFSVLLFQDIAVIPMLALIPLLAIPELVEAGNAH
GGDTGSHDSFNLVEGLAPWASGLVIISSIAFLTIGGHYLSRPLFKFVAASGLREIFTATA
LMLIIGIAALMGLVGLSPALGAFLAGVVLANSEFRHELEANIEPFKGLLLGLFFITVGAG
INFSVLSEGPMLIAGLTAAVMLVKAIVLFIIALIFKIKGTNKWLFTLSLAQAGEFGFVLL
SFASQNYVLPSDIISVLSLVVAISMFLTPGLFILFDKAIIPRYKNAKSQRAEDEIDEKGT
VVIAGIGRFGQIINRLLVANDVNTVVLDIRSEQIDLIRRIGTKAYFGDASKPDILHTAGA
HEASLLVIAIDDKETAAEMVKYAKHAFPNIKVLARAFDRGHGYRLRQLGADFVVSETYHS
ALEMGAEALRSLNIHPFQVERQKMAYKNIEAQQNDVLYHAWADEASGERVDNNYLKLFIE
LESLIENALKADLHDKHSRMRGWTPPPKGYAENLAPDEKPD