Protein Info for MIT1002_01465 in Alteromonas macleodii MIT1002

Annotation: 4-hydroxy-tetrahydrodipicolinate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 68% identical to DAPB_PSEA6: 4-hydroxy-tetrahydrodipicolinate reductase (dapB) from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

KEGG orthology group: K00215, dihydrodipicolinate reductase [EC: 1.3.1.26] (inferred from 95% identity to amc:MADE_02245)

MetaCyc: 58% identical to 4-hydroxy-tetrahydrodipicolinate reductase (Escherichia coli K-12 substr. MG1655)
RXN-14014 [EC: 1.17.1.8]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8)" (EC 1.17.1.8)

MetaCyc Pathways

aspartate superpathway (23/25 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
L-lysine biosynthesis I (9/9 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
L-lysine biosynthesis III (6/7 steps found)
L-lysine biosynthesis VI (6/7 steps found)
L-lysine biosynthesis II (6/9 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.17.1.8 or 1.3.1.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (267 amino acids)

>MIT1002_01465 4-hydroxy-tetrahydrodipicolinate reductase (Alteromonas macleodii MIT1002)
MKVGLFGANGRMGRVLVEALDLSDDAQLSVATVRDDSPWVGLNVGELAGIGKKDVDCTAL
SDLSGNDADVMIDFTLPSVIESNLTWCVKNKMPVVIGTTGLNDSQLAALDEAAKHIPIVF
AANYSVGVNLMLSLVRQAASVLGETADIEITEAHHRFKQDAPSGTAMAIGEAIADELGRD
LKTCAVYGREGKEPERDQGTIGFATIRAGDIVGEHTALFADIGERLEITHKASSRLTFAK
GAVHAAKWLYGKEPGLYSMVDVLDLKL