Protein Info for MIT1002_01428 in Alteromonas macleodii MIT1002

Annotation: Anthranilate synthase component II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02885: Glycos_trans_3N
  • amino acids 6 to 67 (62 residues), 63.4 bits, E=1.4e-21
• TIGR01245: anthranilate phosphoribosyltransferase
  • amino acids 8 to 334 (327 residues), 400.9 bits, E=2.5e-124
• PF00591: Glycos_transf_3
  • amino acids 75 to 323 (249 residues), 318.3 bits, E=4.1e-99

Best Hits

Swiss-Prot: 58% identical to TRPD_PSEA6: Anthranilate phosphoribosyltransferase (trpD) from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

KEGG orthology group: K00766, anthranilate phosphoribosyltransferase [EC: 2.4.2.18] (inferred from 95% identity to amc:MADE_02290)

Predicted SEED Role

"Anthranilate phosphoribosyltransferase (EC 2.4.2.18)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 2.4.2.18)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• L-tryptophan biosynthesis (6/6 steps found)
• superpathway of chorismate metabolism (42/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.18

Use Curated BLAST to search for 2.4.2.18

Protein Sequence (343 amino acids)

>MIT1002_01428 Anthranilate synthase component II (Alteromonas macleodii MIT1002)
MLNAGPLLEQIMLRESLSQTEAYSLFNSIMHGEQSEVMIASVLTALKMKKESPSEIAGAA
SAMVANALPFPTPSYEFADIVGTGGDGHNTINISSAAGVVAASCGVKVAKHGNRSVSSKS
GSADLFRQFGLNLEISPETSRKCLDEANFTFLFAPVYHAGMRHAAPVRAAMKTRTLFNIL
GPLANPAGPTHGVFGVYSPELLEPYAKTLMLLGQHRAMIVHGDGLDELALHGESMIYDLE
HGDIRKLTVTAEDFGLPHYPLSAIEGGEPEENRQFVEAALNGEGKEAHRAAIAMNCGALL
KVTGKASTFKEGAEMAMNAMAEGLPMQSLTKVAKITQEVSTNG