Protein Info for MIT1002_01263 in Alteromonas macleodii MIT1002

Annotation: 7-cyano-7-deazaguanine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 PF00733: Asn_synthase" amino acids 5 to 99 (95 residues), 25.9 bits, see alignment E=8e-10 PF06508: QueC" amino acids 5 to 209 (205 residues), 231.7 bits, see alignment E=6.9e-73 TIGR00364: queuosine biosynthesis protein QueC" amino acids 6 to 202 (197 residues), 215.4 bits, see alignment E=3e-68

Best Hits

Swiss-Prot: 95% identical to QUEC_ALTMD: 7-cyano-7-deazaguanine synthase (queC) from Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)

KEGG orthology group: K06920, queuosine biosynthesis protein QueC (inferred from 95% identity to amc:MADE_02725)

Predicted SEED Role

"Queuosine Biosynthesis QueC ATPase" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (218 amino acids)

>MIT1002_01263 7-cyano-7-deazaguanine synthase (Alteromonas macleodii MIT1002)
MSENVVVIYSGGMDSFTVLHKALKAGKKVHALSFNYGQRHKKELDYAANVCNSLNVPHKI
VDISAINTLIGGSALTSDIEVPEGHYEEPSMKQTVVPNRNMILLSLAVGYAVSLDANEVY
YGAHSGDHAIYPDCRPEFVHKMNDVCGIANYTPVTIMTPYIDDSKTAILTDGLSMGLDYG
QTWTCYNGREKACGKCGACEERLEAFKENNAVDPLEYE