Protein Info for MIT1002_01179 in Alteromonas macleodii MIT1002

Annotation: putative amino-acid metabolite efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 309 transmembrane" amino acids 14 to 32 (19 residues), see Phobius details amino acids 42 to 63 (22 residues), see Phobius details amino acids 76 to 100 (25 residues), see Phobius details amino acids 105 to 124 (20 residues), see Phobius details amino acids 133 to 149 (17 residues), see Phobius details amino acids 155 to 173 (19 residues), see Phobius details amino acids 185 to 207 (23 residues), see Phobius details amino acids 221 to 242 (22 residues), see Phobius details amino acids 251 to 269 (19 residues), see Phobius details amino acids 275 to 294 (20 residues), see Phobius details PF00892: EamA" amino acids 13 to 147 (135 residues), 81.9 bits, see alignment E=2.5e-27 amino acids 159 to 291 (133 residues), 57.9 bits, see alignment E=6.4e-20

Best Hits

KEGG orthology group: None (inferred from 97% identity to amc:MADE_02797)

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (309 amino acids)

>MIT1002_01179 putative amino-acid metabolite efflux pump (Alteromonas macleodii MIT1002)
MSSSSVTEKEQSKGIKMLLVAVLCLGLNWPGMKLGLEIVGPVWMVCLRFLLSLPVLALFV
LITKKHLPVLNRKDRSVVFVVAFFQFILSMGLITVSLQFIPAGTASILIYTTPLWMLLID
TLWYRQRPPSKRLILTGISTIGCAMILFASGQPGAWLPLFGMLLASALWAVAIRRVSFHK
WKGSVIEAVFWQFTIAGFAMLAIALLVEPTPNFGTYDISDWLLLAYIGPVATGLGFGLMV
AAGPKLPPDKIVLISTLTPIVGYVSSVILLKETLLPMVMAGAILMIAALIVNGLPQSTLK
KILGKGHAK