Protein Info for MIT1002_00925 in Alteromonas macleodii MIT1002

Annotation: sodium/calcium exchanger 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 917 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 880 to 899 (20 residues), see Phobius details TIGR04312: choice-of-anchor B domain" amino acids 159 to 546 (388 residues), 449.7 bits, see alignment E=4.6e-139 PF08309: LVIVD" amino acids 206 to 231 (26 residues), 9.2 bits, see alignment (E = 0.00017) amino acids 475 to 508 (34 residues), 20.6 bits, see alignment (E = 4.4e-08) PF03160: Calx-beta" amino acids 553 to 656 (104 residues), 26.1 bits, see alignment E=1.5e-09 amino acids 661 to 772 (112 residues), 63.4 bits, see alignment E=4.2e-21 PF17963: Big_9" amino acids 775 to 862 (88 residues), 24.7 bits, see alignment E=7.3e-09 PF22352: K319L-like_PKD" amino acids 782 to 863 (82 residues), 54 bits, see alignment E=2.8e-18

Best Hits

Predicted SEED Role

"FIG01065953: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (917 amino acids)

>MIT1002_00925 sodium/calcium exchanger 1 (Alteromonas macleodii MIT1002)
MNAFPLTLIVLLLAFVSQGAQAHTDHDKARFVAEDGVDAGKCDNRFRPCKTLSYAARQAN
KGDKILVAEGQYYFDNAQHAQVLNDSLLPVLGGFSREDHYQAQKPALHKTTLVNVPTYLS
EALYEKGFDSITDGKAASSLQTQASSHMVLSSEVSANEACTDGTAADFPCSNIDLLSNVP
VNVLSSVSNSTNDIWGHVDLNNRREYAIVGMQASIAVVDVTEPTAPVVVGEITGQSTTWR
DIKVYQYFDSAAGRFKAYAYASADSVTEGFTIIDLNDLPNGISLTKRINDDNRAHNIYIS
NVDYTLNTPLNGAAPQLHLVGQDSNGGAFRSYTLTSPQTPTASYIPSGLTRADYTHDASS
MRVTDARAQTDCVNATADGCTVMLDFNEDAMRLWDHTNTNSTSELSSISYNEVAYTHSGW
FSEDKQYAFVHDELDERNFSLNTRVMIFDISSLTTPVLASIWTSDNGTIDHNGYVRGNRY
YMSNYERGLTVLDISDPTAPVEAGFFDTYPAFNSTNFNGAWGVYPFLPSGNILVSDIQRG
LFVLKDNTLSATTVAGFSQANYETDADTTLSLPVNKTGTGAMTVAYEVIAGSATSSDVML
ASGELSWGADESQAKNITLSIGANENTESNEVFFVRLFNPQGGGIASVSGYARVTISGTA
QQGKIELSAGERAVLETDSELALNIVRQGGSEGEVSVNYSLESGTAVSDEDFVNQSGTLT
WSDGDTSSKTVNITLINDSIEEDNEQFRLVLAAQDTNLLGGVVETLITIKDDESNQAPVV
NAGTDVETDVRASVELTGSAQDPEGALTSVEWTQTAGDTVTIRNADTLTMSFTAPSSQSN
LTFSLTATDEFGVSASDTVTVTVNESVVSLPTDTNSNSSGGGGSTTLFSILGLALALGWR
RVKLPNKAHKLQLSEQK