Protein Info for MIT1002_00832 in Alteromonas macleodii MIT1002

Annotation: Arabinose 5-phosphate isomerase KdsD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 PF01380: SIS" amino acids 43 to 174 (132 residues), 117 bits, see alignment E=5.4e-38 TIGR00393: sugar isomerase, KpsF/GutQ family" amino acids 47 to 315 (269 residues), 364.9 bits, see alignment E=1.4e-113 PF00571: CBS" amino acids 203 to 259 (57 residues), 23.1 bits, see alignment E=7.7e-09 amino acids 270 to 323 (54 residues), 23.7 bits, see alignment 4.8e-09

Best Hits

Swiss-Prot: 58% identical to KDSD_PSEAE: Arabinose 5-phosphate isomerase KdsD (kdsD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K06041, arabinose-5-phosphate isomerase [EC: 5.3.1.13] (inferred from 91% identity to amc:MADE_03188)

MetaCyc: 56% identical to D-arabinose 5-phosphate isomerase KdsD (Escherichia coli K-12 substr. MG1655)
Arabinose-5-phosphate isomerase. [EC: 5.3.1.13]

Predicted SEED Role

"Arabinose 5-phosphate isomerase (EC 5.3.1.13)" in subsystem KDO2-Lipid A biosynthesis (EC 5.3.1.13)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (326 amino acids)

>MIT1002_00832 Arabinose 5-phosphate isomerase KdsD (Alteromonas macleodii MIT1002)
MNTQTQMNYIDSAKRVIEIETQAIANLAERLNNEFIAACNILFACKGKVVVSGMGKSGHI
GNKIAATLASTGTPAFFMHPGEANHGDLGMLSKGDVLLAISNSGETNELVNLLPVVKRLG
IQVVAMTNSASSSLGQHADVVLDISVEKEACSLGLAPTSSTTATLVMGDALAVALLDQKG
FTSDDFALSHPGGSLGRKLLLKVSDIMQSGSDIPLVHASASVADALLEISKKGLGMTGVI
AADGALTGVFTDGDLRRILDARVDVHSATVEEVMTKGGKTTTAGQLAVEALNLMETHKIS
ALMVTDDKRKPVGAFNMHMLLKAGVL