Protein Info for MIT1002_00783 in Alteromonas macleodii MIT1002

Annotation: Peptidyl-prolyl cis-trans isomerase SurA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF13624: SurA_N_3" amino acids 17 to 140 (124 residues), 47 bits, see alignment E=7.6e-16 PF09312: SurA_N" amino acids 25 to 142 (118 residues), 131 bits, see alignment E=7.4e-42 PF13623: SurA_N_2" amino acids 34 to 105 (72 residues), 29.4 bits, see alignment E=2.1e-10 PF13616: Rotamase_3" amino acids 164 to 273 (110 residues), 54.5 bits, see alignment E=5.2e-18 amino acids 281 to 382 (102 residues), 78.8 bits, see alignment E=1.4e-25 PF00639: Rotamase" amino acids 178 to 271 (94 residues), 70.2 bits, see alignment E=7.6e-23 amino acids 288 to 380 (93 residues), 84.6 bits, see alignment E=2.4e-27 PF13145: Rotamase_2" amino acids 300 to 383 (84 residues), 35.5 bits, see alignment E=4.8e-12

Best Hits

Swiss-Prot: 68% identical to SURA_PSEA6: Chaperone SurA (surA) from Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 94% identity to amc:MADE_03412)

MetaCyc: 46% identical to chaperone SurA (Escherichia coli K-12 substr. MG1655)
Peptidylprolyl isomerase. [EC: 5.2.1.8]

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (427 amino acids)

>MIT1002_00783 Peptidyl-prolyl cis-trans isomerase SurA (Alteromonas macleodii MIT1002)
MKFIIRALMLGALLSFNSVAQEVMLDRVAVIVDQGVVLESEIDALVQDVKRNAEANNQQL
PSDRALRTQAIERLITKSLQLQMAERMGIRISDPQLEQTISNIAANQNATIEELRAQLAA
EGIAYDDYREDIREEVIMGEVRRANVRRRVYITPQEIETLIDLMEQQGATQAEYRLGHIL
IGFPPEPTDEDIQSARERADKVISLLESGSDFAKIAIASSSGNEALEGGDMGWLNINAMP
TLFAEAIQNKDKDALVGPIRSGAGFHILKVLDTRGIEKVTVEEVNSRHILVKPSIILSED
KAKAMLNRFKEEVKNGEADFAELAKEHSEDPGSALRGGELGWSDPNNYVPEFKDALAQLE
PGEFSEPVRTVHGWHLIQLIERRIDDATDKRKEDKAYQLIFNRKFSEETENWLREMRDAA
YVEVVDS