Protein Info for MIT1002_00688 in Alteromonas macleodii MIT1002

Annotation: Peptidyl-prolyl cis-trans isomerase A precursor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 202 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00160: Pro_isomerase" amino acids 40 to 198 (159 residues), 131 bits, see alignment E=2.5e-42

Best Hits

KEGG orthology group: K03767, peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC: 5.2.1.8] (inferred from 96% identity to amc:MADE_03671)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiA precursor (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (202 amino acids)

>MIT1002_00688 Peptidyl-prolyl cis-trans isomerase A precursor (Alteromonas macleodii MIT1002)
MKKILLSLLTAIMLIGSISPVMAKKDDGSQVQPDNYYPRVKIETTMGDIVVELDRRRAPI
TVNNFLRYVDKRAYEDTIFHRIVPGFVVQGGGYTADFNGKSNFPDIFNESGNGLTNDLHT
IAMARQGDPHTANRQFFFNVNDNSSLNPGRDWGYAVFGVIVEGEDIVDAMSEVETEYSIR
LNANNVPIEPIIIKKMTVLPPL