Protein Info for MIT1002_00539 in Alteromonas macleodii MIT1002

Annotation: Malate-2H(+)/Na(+)-lactate antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 458 transmembrane" amino acids 22 to 45 (24 residues), see Phobius details amino acids 69 to 87 (19 residues), see Phobius details amino acids 113 to 137 (25 residues), see Phobius details amino acids 150 to 176 (27 residues), see Phobius details amino acids 188 to 210 (23 residues), see Phobius details amino acids 243 to 263 (21 residues), see Phobius details amino acids 275 to 293 (19 residues), see Phobius details amino acids 313 to 333 (21 residues), see Phobius details amino acids 336 to 343 (8 residues), see Phobius details amino acids 346 to 365 (20 residues), see Phobius details amino acids 372 to 397 (26 residues), see Phobius details amino acids 436 to 457 (22 residues), see Phobius details PF03553: Na_H_antiporter" amino acids 172 to 452 (281 residues), 142.3 bits, see alignment E=1e-45

Best Hits

KEGG orthology group: None (inferred from 97% identity to amc:MADE_00591)

Predicted SEED Role

"Na+/H+ antiporter" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (458 amino acids)

>MIT1002_00539 Malate-2H(+)/Na(+)-lactate antiporter (Alteromonas macleodii MIT1002)
MDWMSVIPPLVAIAVVFWKKEVILALALAVLCAEALILVNADIAGSYMAPINAIERVVDT
AASPGNTRVLIFSVLVGALLAFIRDSGGVTATVNFLVNKGVAKSRKQVGGLTMFTGIAVF
IESNLSVLTAGIFARGLFDRFGMSRARLAYIIDSTSAPVCILILLNGWGAFILSLLDAYE
LPASSASVLWGSVFFNFYAIFTLLIVAYTISADKVHGPMAEEEKALTHVEVNQTTEPATK
ARFMLVPLIIMVLSMVGFMFWTGNGVLSEGSGSKSVLYATALATAIAYGLLLIHKRFTHK
EAVEIGFKGMGELLPLVTIVLLSLTLGNSLKVLGTGVFVAGIVGEYLPLVLIVPMLFIAG
AIMSFTTGTSWGTFAILIPIGVPLIQSLGLPPSLVIGAILGGGIFGDHCSPISDTTAVSS
LAAGTDVLTHVKTQFPYALFAGALTLIAYFVASLVMLG