Protein Info for MIT1002_00477 in Alteromonas macleodii MIT1002

Annotation: Response regulator ArlR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 252 PF00072: Response_reg" amino acids 25 to 135 (111 residues), 101.9 bits, see alignment E=3.6e-33 PF00486: Trans_reg_C" amino acids 174 to 247 (74 residues), 66.6 bits, see alignment E=2.6e-22

Best Hits

Swiss-Prot: 38% identical to MPRA_MYCVP: Response regulator MprA (mprA) from Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)

KEGG orthology group: K07662, two-component system, OmpR family, response regulator CpxR (inferred from 97% identity to amc:MADE_00535)

Predicted SEED Role

"Copper-sensing two-component system response regulator CpxR" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (252 amino acids)

>MIT1002_00477 Response regulator ArlR (Alteromonas macleodii MIT1002)
MNQRSAVPTVKEFNTMSSDFHLQSILVIDDDLELTEMLSTYLSSMGYQVQVCNDGEEGLS
EAVSGRHYDLILLDVMMPKMDGFDVLKKLRVSHSTPVLMLTARGDDYDRILGLEMGADDY
LPKPFNHRELVARIKAIVRRHNLSSTGGAVEQDLFVNGIFLSPSSQLAKVDDVELTLTTT
EFLILRLLMLNAAQRVTKEEISLKILGKPLQAFDRSIDMHVSNLRKKISAVAVDEKIKTI
RGVGYMLIVGSH