Protein Info for MIT1002_00298 in Alteromonas macleodii MIT1002

Annotation: Cation efflux system protein CzcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 transmembrane" amino acids 13 to 31 (19 residues), see Phobius details amino acids 346 to 363 (18 residues), see Phobius details amino acids 368 to 387 (20 residues), see Phobius details amino acids 394 to 414 (21 residues), see Phobius details amino acids 451 to 470 (20 residues), see Phobius details amino acids 481 to 507 (27 residues), see Phobius details amino acids 537 to 556 (20 residues), see Phobius details amino acids 874 to 893 (20 residues), see Phobius details amino acids 900 to 919 (20 residues), see Phobius details amino acids 926 to 950 (25 residues), see Phobius details amino acids 971 to 991 (21 residues), see Phobius details amino acids 1003 to 1026 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1034 (1034 residues), 1507.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1029 (1025 residues), 1036.4 bits, see alignment E=0

Best Hits

Swiss-Prot: 59% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 100% identity to amc:MADE_00374)

MetaCyc: 59% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1035 amino acids)

>MIT1002_00298 Cation efflux system protein CzcA (Alteromonas macleodii MIT1002)
MIDNIIRLSVERRFLFLVLALILIGIGVWSYQRLPIDAVPDITNVQVQINTKAPGYSPLE
AEQRITFPVETALYGLPNLSYTRSISRYGLSQITVIFEEGTDIFFARNLIDERLANLKSV
LPDGLEPEMGPIATGLGEIFVYTLEGKDGATLPDGSPVTPMALREVQDWIIRPQLAQVPG
VVEVNTIGGYDKQYHVNPDPVKMLEMGVSLKDISEALYLNNDNAGAGYIEKNGEQLLVRS
PGQLTGIKDIENVVVGKKGSVPVLIKDIGTVGLGKQLRTGAATRNGKETVMGTVMMLLGE
NSREVAALTASKLTEIQRSLPSWVVTEPAYDRTTLVDKAINTVQKNLLEGALLVIVILFL
LLGNIRAALITAAIIPIAMMMTITGMVQRGVSANLMSLGALDFGLIVDGAVIIVENCIRR
LSEAQQHHGRLLQLKERLEEVKIATIEVIRPSLFGVGIITAVYLPIFTLTGVEGKMFHPM
AITVVIALIAAMILSLTVVPAAIAIFMGGKISEKESFLIRWVKLAYEPALRAILKFKAAA
LGAALAFVVFCGWLATTLGSEFIPQLDEGDVALQALRITGTGLNQSIQMQELLEGALLEI
PEVAVVFAKIGTPEVATDPMPPNVADSFVILKPRSEWPDPAKSKSDLVAEIESVASKLPG
NNYEFTQPIQMRFNELISGVRADVAVKVFGDDLEQLLDSANKVAEIAESIQGASDTRVEQ
VAGLPMLSILPKRDALARYGLNVADIQALVSTSIGGKESGIIYEGDRRFKIVIRLSEELR
TNIDKLESLPVRVGNSFVPLEEVATLELKPAPAQISRENGKRRVVVTTNVRGTDLGGFVV
DLQKRLKSDLKMKEGYWLEFGGTFEQLESASKRLTLVVPVTLALIVGILIMAFGSVKDAL
IIFTGVPLALTGGVLALWIRDMPLSISAGVGFIALSGVAVLNGLVMVAFIRQLWQENGDI
YTSVIRGAIIRLRPVLMTALVASLGFVPMALNTGTGAEVQRPLATVVIGGIISSTLLTLF
ILPALYQLAHNKRNS