Protein Info for MIT1002_00128 in Alteromonas macleodii MIT1002

Annotation: Diguanylate cyclase DosC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 519 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 136 to 157 (22 residues), see Phobius details amino acids 167 to 184 (18 residues), see Phobius details amino acids 197 to 219 (23 residues), see Phobius details amino acids 236 to 254 (19 residues), see Phobius details amino acids 266 to 286 (21 residues), see Phobius details amino acids 293 to 312 (20 residues), see Phobius details amino acids 318 to 338 (21 residues), see Phobius details PF07695: 7TMR-DISM_7TM" amino acids 139 to 340 (202 residues), 51.1 bits, see alignment E=1.7e-17 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 356 to 513 (158 residues), 133 bits, see alignment E=4.4e-43 PF00990: GGDEF" amino acids 357 to 512 (156 residues), 123.1 bits, see alignment E=9.5e-40

Best Hits

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (519 amino acids)

>MIT1002_00128 Diguanylate cyclase DosC (Alteromonas macleodii MIT1002)
MACGVSRNFVRLLFGLILLTFGTFANAACVINAENGTSDTDTDSALSIVLKEGAQRLSLS
CDVNATHVLYFPRNYLSYNQLYDSEMQKVPKLTGAFESYAIDNTHKRLFLDINSQVQRPV
RLNIATLNDFQTLASIHTFTLSLFIGFCLALTLYVGMLGTSMRNYGFYSYSFYVLSAAIF
FLLQEGLLNIAFPHVAFFSNFKLHLLFAGITVFAAVKFLDQLLDFKALLKVWQRQFILGM
ACSALALSFVQIILSTSDAMRVNSTLSLITLITMTCTLSSCVYAAYREVHCSNLVLMGIA
VMVFSMMFRLVFSDVSAFMYRYGLIVGITIEAFIFAIATSRKVKKLDDDRLSAFKRASTD
SLCKVLNRSGWEGIAQSLLTNFNKEGGYLTLLFIDVDNFKEINDHYGHHCGDKVLQVIAK
ILLSRCRDQDAVGRLGGDEFVVLSHCYSEGQSERLAARIEASLLERDIRTDNVVISVTAS
VGTYITNERCKDLTTLLNKADKLMYSVKEKHKTAQLASS