Protein Info for MCAODC_27135 in Escherichia coli ECRC101

Name: hyi
Annotation: hydroxypyruvate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03234: hydroxypyruvate isomerase
  • amino acids 3 to 255 (253 residues), 418.2 bits, E=5.5e-130
• PF01261: AP_endonuc_2
  • amino acids 21 to 256 (236 residues), 170.2 bits, E=3.4e-54

Best Hits

Swiss-Prot: 99% identical to HYI_ECOLI: Hydroxypyruvate isomerase (hyi) from Escherichia coli (strain K12)

KEGG orthology group: K01816, hydroxypyruvate isomerase [EC: 5.3.1.22] (inferred from 99% identity to eco:b0508)

MetaCyc: 99% identical to hydroxypyruvate isomerase (Escherichia coli K-12 substr. MG1655)
Hydroxypyruvate isomerase. [EC: 5.3.1.22]

Predicted SEED Role

"Hydroxypyruvate isomerase (EC 5.3.1.22)" (EC 5.3.1.22)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.22

Protein Sequence (258 amino acids)

>MCAODC_27135 hydroxypyruvate isomerase (Escherichia coli ECRC101)
MLRFSANLSMLFGEYDFLARFEKAAQCGFRGVEFMFPYDYDIEELKQVLASNKLEHTLHN
LPAGDWAAGERGIACIPGREEEFRDGVAAAIRYARALGNKNINCLVGKTPAGFSSEQIHA
TLVENLRYAANMLMKEDILLLIEPINHFDIPGFHLTGTRQALKLIDDVGCCNLKIQYDIY
HMQRMEGELTNTMTQWADKIGHLQIADNPHRGEPGTGEINYDYLFKVIENSDYNGWVGCE
YKPQTTTEAGLRWMDPYR