Protein Info for MCAODC_04285 in Escherichia coli ECRC101

Name: fpr
Annotation: ferredoxin--NADP(+) reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00970: FAD_binding_6
  • amino acids 18 to 90 (73 residues), 30.3 bits, E=4.3e-11
• PF00175: NAD_binding_1
  • amino acids 111 to 222 (112 residues), 67.5 bits, E=1.6e-22

Best Hits

Swiss-Prot: 100% identical to FENR_SHIFL: Flavodoxin/ferredoxin--NADP reductase (fpr) from Shigella flexneri

KEGG orthology group: K00528, ferredoxin--NADP+ reductase [EC: 1.18.1.2] (inferred from 100% identity to eok:G2583_4729)

MetaCyc: 99% identical to flavodoxin/ferredoxin-NADP+ reductase (Escherichia coli K-12 substr. MG1655)
FLAVONADPREDUCT-RXN [EC: 1.19.1.1]

Predicted SEED Role

"Ferredoxin--NADP(+) reductase (EC 1.18.1.2)" in subsystem Biogenesis of cytochrome c oxidases (EC 1.18.1.2)

MetaCyc Pathways

• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (19/26 steps found)
• ethene biosynthesis V (engineered) (18/25 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (19/27 steps found)
• oxygenic photosynthesis (11/17 steps found)
• superpathway of photosynthetic hydrogen production (3/6 steps found)
• NADPH to cytochrome c oxidase via plastocyanin (thylakoid membrane) (1/4 steps found)
• photosynthesis light reactions (1/4 steps found)

KEGG Metabolic Maps

• Photosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.18.1.2 or 1.19.1.1

Protein Sequence (248 amino acids)

>MCAODC_04285 ferredoxin--NADP(+) reductase (Escherichia coli ECRC101)
MADWVTGKVTKVQNWTDALFSLTVHAPVHPFTAGQFTKLGLEIDGERVQRAYSYVNSPDN
PDLEFYLVTVPDGKLSPRLAALKPGDEVQVVSEAAGFFVLDEVPDCETLWMLATGTAIGP
YLSILQLGKDLDRFKNLVLVHAARYAADLSYLPLMQELEKRYEGKLRIQTVVSRETAAGS
LTGRIPALIESGELESAIGLPMNKETSHVMLCGNPQMVRDTQQLLKETRQMTKHLRRRPG
HMTAEHYW