Protein Info for LU632_RS20435 in Erwinia tracheiphila SCR3

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 561 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 44 to 63 (20 residues), see Phobius details amino acids 74 to 94 (21 residues), see Phobius details amino acids 104 to 128 (25 residues), see Phobius details amino acids 140 to 162 (23 residues), see Phobius details amino acids 174 to 195 (22 residues), see Phobius details PF07694: 5TM-5TMR_LYT" amino acids 29 to 196 (168 residues), 181.2 bits, see alignment E=2.6e-57 PF06580: His_kinase" amino acids 370 to 447 (78 residues), 80.4 bits, see alignment E=1.9e-26 PF02518: HATPase_c" amino acids 469 to 558 (90 residues), 28.2 bits, see alignment E=4.4e-10

Best Hits

Swiss-Prot: 74% identical to BTSS_ECOLI: Sensor histidine kinase BtsS (btsS) from Escherichia coli (strain K12)

KEGG orthology group: K02478, two-component system, LytT family, sensor kinase [EC: 2.7.13.3] (inferred from 77% identity to set:SEN2153)

MetaCyc: 74% identical to high-affinity pyruvate receptor (Escherichia coli K-12 substr. MG1655)
Histidine kinase. [EC: 2.7.13.3]

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (561 amino acids)

>LU632_RS20435 sensor histidine kinase (Erwinia tracheiphila SCR3)
MYNVDLVLLLLQQMCVFLVIAWLMSKTRLLTPLMQITVRLPHKLLCYVTFSVFCILGTFL
SLHIEDSLANTRAIGAAIGGLLGGPLTGGLIGLTGGLHRYTLGGMTAISCMISTLAEGVI
GGLLQRWLINTGRSDKVLSPLTAGCVTLLTELVQMAIILLIARPFQDALHLVKNIALPMV
VTNSLGAAMFMRILLDKRAMFEKYTPAFSAVALKVAASTEGILRMGFNEENSHKVAQILY
SELKTGAVAITDREKLLAFTGIGNDHHLPGEQIASSWTLRAIQTGEVVYTDGNETPYRCS
IHPACKLSSTLVIPLHGENQRVIGTIKLYEAKHRLFSSINRALGEGIARLLSAQILAGNY
EQQKALLAQAEIQLLHARVNPHFLFNALNTLLAVIRRDQQQAGQLVQYLSTFFRKNLKRP
SQIVTLTDETEHVDAYLNIEKARFQTSLTVRLDIPSTLSHFQLPAFSLQPIVENAIKHGT
SQLSGQGEILIKAFKEAEHLILTIEDNAGLYQQQHHPEGMGMALVDKRLRAHFGAGYGIT
IHCEPDHFTRISLQLPLEKRC