Protein Info for LU632_RS17770 in Erwinia tracheiphila SCR3

Annotation: glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 810 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 40 to 61 (22 residues), see Phobius details amino acids 68 to 91 (24 residues), see Phobius details amino acids 97 to 114 (18 residues), see Phobius details amino acids 126 to 146 (21 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 19 to 809 (791 residues), 1077.2 bits, see alignment E=0 PF01011: PQQ" amino acids 456 to 482 (27 residues), 25 bits, see alignment (E = 1.7e-09) amino acids 737 to 774 (38 residues), 29.6 bits, see alignment 6.2e-11 PF13360: PQQ_2" amino acids 686 to 771 (86 residues), 29.4 bits, see alignment E=9.3e-11

Best Hits

Swiss-Prot: 66% identical to QUIA_ACIAD: Quinate/shikimate dehydrogenase (quinone) (quiA) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K05358, quinate dehydrogenase (quinone) [EC: 1.1.5.8] (inferred from 85% identity to ebi:EbC_33710)

MetaCyc: 66% identical to quinate/shikimate dehydrogenase (quinone) (Acinetobacter baylyi ADP1)
1.1.99.25-RXN [EC: 1.1.5.8]; 1.1.5.8 [EC: 1.1.5.8]

Predicted SEED Role

"Quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (EC 1.1.99.25)" in subsystem Chorismate Synthesis or Quinate degradation (EC 1.1.99.25)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.5.8 or 1.1.99.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (810 amino acids)

>LU632_RS17770 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase (Erwinia tracheiphila SCR3)
MSEINSRASKMLGLWCFALGGLFLAAGLCFIIGGGKLISLGGSAYFLIAGIFIVISAIQF
FRCKSSAVLTFTLVFIGSVIWAALDVGFYFWPLVSRLMTLAGFLLLATITLPALRKHEGK
SSAARASYALSAIVLTGMVVTLVQMFQPHPAVQEGHSLPLIPVTEDQQQKNWDNYGNTPG
GNRFVALDQITRDNVNNLKVAWIFHTGDIPLSPDGNGAEDQQTPLQVGNTVFLCTPHNNV
IAVAADSGKSIWKAEINAKSSVWMRCRGLAYFDATRPLIQPAAPDSVPPAPVNLAADAAC
QRRILMNTIDARLMAFDADTGKACADFGHNGTVNLREGMGEAKDPSYVLTSAPTVAGTTV
VVGGRVADNVSTDMPGGVIRGFDVITGKLRWAFDPGKDEPNAPLASGDHYTRSTPNSWAP
MSYDANMNTVFIPMGSSSVDLWGVNRTKLDHKYGSAVLALDATSGKERWVYQTVHNDLWD
FDLPMQPSLIDFPMKDGVSKPAVAIGTKSGQIYVLDRQTGQPLTKVVEQPVPQANIPGEQ
YSRTQPRSVGMPQIGNETLKESDMWGATPFDQLACRISFKSMRYSGLYTAPGTDKSLSFP
GSLGGMNWGSMSTDPNHHYLFINDMRLGLWQQMVPAAPAKNGAVSNGGEAVNTGMGVVPM
KGTPYAVNKNRFMSPLGIPCQKPPFGTLSAVDLKTQKVVWQVPLGTVQDTGPFGIKMHAQ
MPVGMPSLGGSLATQGGLVFIAGTQDYYLRAFDTATGKEVWKARLPVGSQGGPISYVSPQ
NGKQYILISAGGARQSPDRGDYVIAFALDK