Protein Info for LU632_RS15300 in Erwinia tracheiphila SCR3

Name: copA
Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 837 transmembrane" amino acids 190 to 207 (18 residues), see Phobius details amino acids 218 to 239 (22 residues), see Phobius details amino acids 255 to 278 (24 residues), see Phobius details amino acids 284 to 303 (20 residues), see Phobius details amino acids 437 to 459 (23 residues), see Phobius details amino acids 465 to 487 (23 residues), see Phobius details amino acids 779 to 798 (20 residues), see Phobius details amino acids 804 to 823 (20 residues), see Phobius details PF00403: HMA" amino acids 105 to 161 (57 residues), 57.6 bits, see alignment 2.7e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 235 to 828 (594 residues), 600.3 bits, see alignment E=8.1e-184 TIGR01525: heavy metal translocating P-type ATPase" amino acids 253 to 828 (576 residues), 596 bits, see alignment E=1.8e-182 TIGR01494: HAD ATPase, P-type, family IC" amino acids 292 to 796 (505 residues), 276.1 bits, see alignment E=8.8e-86 PF00122: E1-E2_ATPase" amino acids 321 to 501 (181 residues), 175.5 bits, see alignment E=1.6e-55 PF00702: Hydrolase" amino acids 519 to 733 (215 residues), 118 bits, see alignment E=1.5e-37

Best Hits

Swiss-Prot: 67% identical to COPA_SALTY: Copper-exporting P-type ATPase (copA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 70% identity to eta:ETA_24550)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (837 amino acids)

>LU632_RS15300 copper-exporting P-type ATPase CopA (Erwinia tracheiphila SCR3)
MSHTTVLTLTGLSCGHCVKRVKEFLEKRDDEGHAEVSFSEARILSTASAQALIAVVEQAG
YHASQTEENPLPKSEPLTVPDVAPEALEVDLNKLPAQSENSVNLIIDGMSCASCVTRVEQ
ALTAVPGVSRVRVNLAERTALVTGDAGAGALIESIQRAGYDAEIVEDDRQRRKKQQQAAD
KAIRRFRWQTALALALGVPLMIWGMVGDGMVLTESNRTHWLLSGFLTLLVMVVSGGHFYR
NAWRSLLKKTTTMDTLVALGTTAAWVYSTIVTLWPAAFPPASRHLYYEASAMIIGLINLG
HMLEQRARQRSSQALERLLDLTPATARVVTEGGENIIRLSDVTPGMTLRLATGDRVPVDG
MIVQGRAWLDEAMLTGEPMPQEKSTGENIHAGTVVQDGSVLFIASAVGKNTTLSRIINLV
RQAQSSKPETGRLADRIAAVFVPGVLIIALCSALIWYLLGPAPQLVYTLMVAMTVLMIAC
PCALGLATPMSIIAGVGRAAEAGILIRDADALQRASSLDVLVFDKTGTLTEGAPHIVDIT
LFDDMTESQALSWAAALEQGSQHPLACAICHRAEGIDLPEISQFRTLPGQGVSGNIGETA
LLLGNSMLLSQQNIAITEAAAQIATQSAKGITPVLLAANGKIKAVFSVRDPLRDSSITTL
KRLKNRGYQLMMLTGDNRATALAVAQEAGIEKVIADVLPEGKAEAIRRLQQQGFRVAMIG
DGINDSPALAQADVGIAMGGGSDVAIETAGMTLMRHDLTALADGLAIAKATLRNMKQNLL
GAFIYNALSIPVAAGVLWPFTGTLLSPVVAAAAMALSSVTVVSNANRLLRYRPPAIA