Protein Info for LU632_RS13040 in Erwinia tracheiphila SCR3

Annotation: potassium/proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 575 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 32 to 54 (23 residues), see Phobius details amino acids 60 to 78 (19 residues), see Phobius details amino acids 89 to 114 (26 residues), see Phobius details amino acids 121 to 141 (21 residues), see Phobius details amino acids 185 to 210 (26 residues), see Phobius details amino acids 225 to 254 (30 residues), see Phobius details amino acids 273 to 291 (19 residues), see Phobius details amino acids 298 to 323 (26 residues), see Phobius details amino acids 335 to 356 (22 residues), see Phobius details amino acids 363 to 386 (24 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 386 (372 residues), 203.5 bits, see alignment E=7.5e-64 PF02080: TrkA_C" amino acids 421 to 483 (63 residues), 46.5 bits, see alignment E=4.1e-16 PF03471: CorC_HlyC" amino acids 494 to 569 (76 residues), 39.1 bits, see alignment E=9.4e-14

Best Hits

Swiss-Prot: 78% identical to NHAP2_ECOSM: K(+)/H(+) antiporter NhaP2 (nhaP2) from Escherichia coli (strain SMS-3-5 / SECEC)

KEGG orthology group: K11105, cell volume regulation protein A (inferred from 89% identity to ebi:EbC_24270)

Predicted SEED Role

"Cell volume regulation protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (575 amino acids)

>LU632_RS13040 potassium/proton antiporter (Erwinia tracheiphila SCR3)
MDASAIYSLFIIGAVLVSASILLSSFSSKLGIPILVIFLALGMLAGIDGIGGIAFDNYPA
AYLVSNLALAVILLDGGMRTQASSFKVALGPALSLATVGVLITAGLTGMAAAWLFNLNIM
NGFLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVFLTITLIDMIQQGQ
TGLSWMFVVHLVQQFGLGIVLGIGGGWALLQLINRVSLPAGLYPLLAVSGGILVFALTTV
LEGSGILAVYLCGFVLGNRPIRNRYGILQTFDGMAWLSQIGMFLVLGLLVTPTDLWNIAL
PAMLLSVWLILVARPLSVLAGLLPFRGFNLRERLFISWVGLRGAVPIILAVFPMMAGLPH
ATLFFNIAFFVVLVSLMIQGTSLGLAARKARVIIPPTASPISRVGLDIHPENPWEQFVYQ
LGADKWCVGAVLRDLHMPRETRIAALFRNNQLLHPTGNTRLREGDVLCVIGRERDLPELG
KLFSESPPVALDQRFFGDFILQADTRLLAISEIYGIEIAENMNVQQTLGHHIAGMIGGTP
VVGDQVEWQNMIWTIAEKEGNQIMKIGLRVADNKE