Protein Info for LU632_RS12250 in Erwinia tracheiphila SCR3

Annotation: FdhF/YdeP family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01701: oxidoreductase alpha (molybdopterin) subunit
  • amino acids 14 to 758 (745 residues), 896 bits, E=9.2e-274
• PF00384: Molybdopterin
  • amino acids 109 to 490 (382 residues), 72.6 bits, E=3.3e-24
• PF01568: Molydop_binding
  • amino acids 647 to 753 (107 residues), 30.3 bits, E=3.6e-11

Best Hits

Swiss-Prot: 48% identical to YDEP_ECOLI: Protein YdeP (ydeP) from Escherichia coli (strain K12)

KEGG orthology group: K00123, formate dehydrogenase, alpha subunit [EC: 1.2.1.2] (inferred from 86% identity to ebi:EbC_23470)

Predicted SEED Role

"Putative formate dehydrogenase oxidoreductase protein" in subsystem Formate hydrogenase

MetaCyc Pathways

• formate oxidation to CO₂ (1/1 steps found)
• oxalate degradation VI (1/4 steps found)
• oxalate degradation III (1/5 steps found)
• superpathway of C1 compounds oxidation to CO₂ (4/12 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• purine nucleobases degradation II (anaerobic) (11/24 steps found)

KEGG Metabolic Maps

• Glyoxylate and dicarboxylate metabolism
• Methane metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.2

Protein Sequence (770 amino acids)

>LU632_RS12250 FdhF/YdeP family oxidoreductase (Erwinia tracheiphila SCR3)
MKFKMKIKPYEASAGGWGSLEATTRFVFDSKQVIKNMRNLMRMNKARGFDCPGCAWGDDN
KSTLSFCENGAKAVTWEATRRYVDAAFFAKHSVTTLYQQSDYFLEYQGRLTEPLRYNRET
DHYEPISWDDAFRLIARHIHAMASPDQMELYTSGRASNEASWLYQLFGRMNGSNNFPDCS
NMCHEASGTGLKRSIGVGKGTVRLDDFDHADAIFVFGQNPGTNHPRMLHSLRHAADHGAK
IVTFNTLRERGLERFADPQKLLEVVTSKARTISSSYYQPNLGGDMAAIRGMVKALMEAHR
ASLEKGENGIFDTDFIEMHTEGMDAYLNVVDATSWQNITQQSGLSEIQIREAAAIYQHAD
RVICTWAMGITQHKHSVATVREIVNLQLLFGQLGKKGAGLCPVRGHSNVQGNRTMGIYEK
PSAEFLDSLARHFDFEPPRKAGHNTVEALEAMLRHEVKVLIALGGNLAAAAPDSPRTEEA
LRRCALTVHISTKLNRSHLCPGAVDALILPTLGRSEQDCQSGGPQFITVEDSFSMVHASE
GIGKPIADTQRSETAIVAGIGNAVLGSQKVDWLALTGDYNKIRDHIAATIPGFSNFNARC
DIKGGFYLGNAAAELCFNTRNNKAQFSDACLPTSLFPQLDNDVSVPFTLQTLRSHDQYNT
TIYGLDDRYRGIYGQREVLFINADDMAMLGLEADDKVDIETLWNDGIVRKVSAFKLVPYN
IPRGNLAAYYPETNPLVPLSSYGDDSGTPTSKSIPVKIVLSAVKASQRIA