Protein Info for LU632_RS11305 in Erwinia tracheiphila SCR3

Name: nth
Annotation: endonuclease III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01083: endonuclease III
  • amino acids 4 to 194 (191 residues), 295.9 bits, E=6e-93
• PF00730: HhH-GPD
  • amino acids 34 to 169 (136 residues), 80.7 bits, E=9.7e-27
• PF00633: HHH
  • amino acids 99 to 127 (29 residues), 33.9 bits, 1.9e-12

Best Hits

Swiss-Prot: 87% identical to END3_ECOLI: Endonuclease III (nth) from Escherichia coli (strain K12)

KEGG orthology group: K10773, endonuclease III [EC: 4.2.99.18] (inferred from 90% identity to pwa:Pecwa_2319)

MetaCyc: 87% identical to endonuclease III (Escherichia coli K-12 substr. MG1655)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]; 4.2.99.18 [EC: 4.2.99.18]; 4.2.99.18 [EC: 4.2.99.18]

Predicted SEED Role

"Endonuclease III (EC 4.2.99.18)" in subsystem Control of cell elongation - division cycle in Bacilli or DNA Repair Base Excision (EC 4.2.99.18)

Isozymes

Compare fitness of predicted isozymes for: 4.2.99.18

Use Curated BLAST to search for 4.2.99.18

Protein Sequence (210 amino acids)

>LU632_RS11305 endonuclease III (Erwinia tracheiphila SCR3)
MNKDKRQQILLRLRDNNPHPTTELNFTTPFELLIAVLLSAQATDVSVNKATAKLYPVANT
PAAMLALGVDGVKEYIKTIGLFNSKAENVIKTCRILLDKHQGEIPENREALEALPGVGRK
TANVVLNTAFGWPTIAVDTHIFRVSNRTGFAPGKNVEQVEEKLLKVVPKAFKVDCHHWLI
LHGRYTCIARKPRCSSCLIEDLCEYGDKAE