Protein Info for LU632_RS10160 in Erwinia tracheiphila SCR3

Name: cycA
Annotation: D-serine/D-alanine/glycine transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 27 to 44 (18 residues), see Phobius details amino acids 51 to 73 (23 residues), see Phobius details amino acids 104 to 126 (23 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 163 to 186 (24 residues), see Phobius details amino acids 210 to 231 (22 residues), see Phobius details amino acids 251 to 270 (20 residues), see Phobius details amino acids 285 to 308 (24 residues), see Phobius details amino acids 342 to 364 (23 residues), see Phobius details amino acids 370 to 396 (27 residues), see Phobius details amino acids 416 to 434 (19 residues), see Phobius details amino acids 440 to 458 (19 residues), see Phobius details PF00324: AA_permease" amino acids 26 to 461 (436 residues), 400.1 bits, see alignment E=1.3e-123 PF13520: AA_permease_2" amino acids 30 to 445 (416 residues), 148.3 bits, see alignment E=3.3e-47

Best Hits

Swiss-Prot: 75% identical to CYCA_ECO57: D-serine/D-alanine/glycine transporter (cycA) from Escherichia coli O157:H7

KEGG orthology group: K11737, D-serine/D-alanine/glycine transporter (inferred from 89% identity to ebi:EbC_15680)

MetaCyc: 75% identical to D-serine/alanine/glycine:H+symporter (Escherichia coli K-12 substr. MG1655)
RXN0-5130; RXN0-5201; RXN0-5202; RXN0-5203; TRANS-RXN-62A; TRANS-RXN-62B

Predicted SEED Role

"D-serine/D-alanine/glycine transporter" in subsystem Glycine and Serine Utilization or Pyruvate Alanine Serine Interconversions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>LU632_RS10160 D-serine/D-alanine/glycine transporter (Erwinia tracheiphila SCR3)
MIDQLNKTSSSNEAPGELRRHLHNRHIQLIALGGAIGTGLFMGSGKTISLAGPSIIFVYM
IIGFMLFFVMRAMGELLLSNLEYKSFSDFAADLLGPWAGYFTGWTYWFCWVATGIADVVA
ISSYFQLWFPDFSIWMSALLCIVVFLALNIATVKLFGEMEFWFAIIKIVAIVALIATGIV
LVAIHYPSTYGSTAAVSNIWNHGGMFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETHDP
KNVLPRAINAIPLRIIMFYVFALLVIMAVTPWDQVVASRSPFVEMFVLIGLPAAASIVNF
VVLTSAASSANSGIFSTSRMLYCMAQQGVAHKRFGKLSPRAVPTTGLFFSCLCLLSGVAL
IYLIPNVMEVFTLVTTVSAILFMFVWTIIVCSYLAYRKKHPQLHQASQYKMPLGKLMCWV
CIAFFAFVLVLLSLEEDTRKALIVTPLWFIMLGIGWWLRHRKIGL