Protein Info for LU632_RS09100 in Erwinia tracheiphila SCR3

Annotation: NADP-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 transmembrane" amino acids 125 to 142 (18 residues), see Phobius details PF16884: ADH_N_2" amino acids 9 to 115 (107 residues), 130.5 bits, see alignment E=3.5e-42 PF00107: ADH_zinc_N" amino acids 162 to 302 (141 residues), 77.4 bits, see alignment E=1.5e-25 PF13602: ADH_zinc_N_2" amino acids 195 to 340 (146 residues), 45.7 bits, see alignment E=2.1e-15

Best Hits

Swiss-Prot: 62% identical to CURA_ECOLI: NADPH-dependent curcumin reductase (curA) from Escherichia coli (strain K12)

KEGG orthology group: K07119, (no description) (inferred from 81% identity to ebi:EbC_13360)

MetaCyc: 62% identical to NADPH-dependent curcumin/dihydrocurcumin reductase (Escherichia coli K-12 substr. MG1655)
RXN0-6676; RXN0-6677

Predicted SEED Role

"Putative oxidoreductase YncB"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (347 amino acids)

>LU632_RS09100 NADP-dependent oxidoreductase (Erwinia tracheiphila SCR3)
MPQDKHINRRIVLASRPHGAPCSTNFRMETEHRPVPSAGQVLLRTVWLSLDPYMRGRMND
APSYVAPLQINEVISAGTVAVVEQSCHDDYQPGDWVVSQNGWQDFALSDGKGLFRLSGPV
LNHPSWALGLLGMTGFTAYMGLLDIGNPQPGETVVVAAATGAVGSIVGQIAKLKGCYVVG
IAGGREKCRYAEDVLGFDRCIDHHSTDLAGSLKRYCHDGIDVYFESVGGKVFDAILPLMN
TQGRIPVCGLIAHYNRTDAASGPDQLPQFQSAILRKRLRVQGFIINQDYGHRFDEFFKQM
SQWVAENRFTFPEDITDGLDNAPETFTGMLAGKNFGKVLIKVAGDHP