Protein Info for LU632_RS06525 in Erwinia tracheiphila SCR3

Annotation: Nramp family divalent metal transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 transmembrane" amino acids 19 to 38 (20 residues), see Phobius details amino acids 51 to 73 (23 residues), see Phobius details amino acids 94 to 116 (23 residues), see Phobius details amino acids 122 to 143 (22 residues), see Phobius details amino acids 155 to 175 (21 residues), see Phobius details amino acids 196 to 216 (21 residues), see Phobius details amino acids 237 to 262 (26 residues), see Phobius details amino acids 286 to 312 (27 residues), see Phobius details amino acids 326 to 343 (18 residues), see Phobius details amino acids 349 to 371 (23 residues), see Phobius details amino acids 391 to 409 (19 residues), see Phobius details TIGR01197: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family" amino acids 20 to 377 (358 residues), 310 bits, see alignment E=1.5e-96 PF01566: Nramp" amino acids 38 to 383 (346 residues), 412.3 bits, see alignment E=8.4e-128

Best Hits

Swiss-Prot: 84% identical to MNTH_ERWT9: Divalent metal cation transporter MntH (mntH) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K03322, manganese transport protein (inferred from 87% identity to ebi:EbC_32550)

MetaCyc: 76% identical to Mn2+/Fe2+: H+ symporter MntH (Escherichia coli K-12 substr. MG1655)
RXN0-2421; TRANS-RXN-241

Predicted SEED Role

"Manganese transport protein MntH" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>LU632_RS06525 Nramp family divalent metal transporter (Erwinia tracheiphila SCR3)
MSNGRAEEQAIRRSRKIKFALMGPAFIVAIGYIDPGNFATNIQAGAAYGYQLLWVVVWAN
IMAMVIQLMSAKLGIATNKNLAEHIRDRFPRPAVWFYWVQAEIIAMATDLAEFIGAAMGF
RLIFGISLLQGALLTGVVTFLILMLQKQGKKPLELLIGGLLLFVAAAYVIELFYSQPKFI
ALLQGIAIPSLPTSDAILLAAGVLGATIMPHVIYLHSSLTQSPDGASRAERYVSTRLDVA
IAMTIAGFVNLAMMATAAAAFHFSGHTGIAGLDQAYLTLDPLLGRAASLVFGLSLLAAGL
SSTVVGTMAGQVVMQGFIHVRIPLPVRRLVTMLPSFIVIIAGWEPTRILVLSQVLLSFGI
ALALVPLLIFTGNRELMGDMVNTRLMHNTGKAIVVVVVALNLYLLVSMIL