Protein Info for LRK53_RS17015 in Rhodanobacter sp000427505 FW510-R12

Annotation: dipeptide epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 PF02746: MR_MLE_N" amino acids 13 to 124 (112 residues), 72.6 bits, see alignment E=4.9e-24 PF13378: MR_MLE_C" amino acids 147 to 354 (208 residues), 183.1 bits, see alignment E=9.6e-58 PF07476: MAAL_C" amino acids 235 to 314 (80 residues), 33 bits, see alignment E=5.7e-12

Best Hits

Swiss-Prot: 54% identical to AEEP_CLOAB: L-Ala-D/L-Glu epimerase (CA_C0192) from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)

KEGG orthology group: None (inferred from 80% identity to sml:Smlt0458)

Predicted SEED Role

"L-alanine-DL-glutamate epimerase" in subsystem Muconate lactonizing enzyme family

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (365 amino acids)

>LRK53_RS17015 dipeptide epimerase (Rhodanobacter sp000427505 FW510-R12)
MKITDIQFGMLRVPLKTPFKTALRTVNTVEDIVVMVHTDSGQVGYGEAPATAVITGDTHG
SIIDAIRHYISPRLIGQDIANLNHLTQLIQSSMEKNTSAKAAVEIALYDLWGQLYGAPLY
KLLGGGDPVITTDITISVDYIDKMVADSVSAVERGFESLKIKVGKDIGVDIERVKAIYAA
VEGRALLRLDANQGWTAKQAVYALQTLEDAGIKLELIEQPVKARDLAGMRYVTERVHTPV
MADESVFGPMEVIELIRLRAADIINIKLMKTGGISNAVRIADIAGMHGVECMIGCMLETS
ISVAAAVHVAVAKSNVITKVDLDGPSLCQFNPVDGGVIFNESEISVTDAPGLGIREIRGL
ERIEA