Protein Info for LRK53_RS12905 in Rhodanobacter sp000427505 FW510-R12

Annotation: M28 family peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 769 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF02225: PA" amino acids 157 to 244 (88 residues), 38.1 bits, see alignment E=2.1e-13 PF04389: Peptidase_M28" amino acids 338 to 549 (212 residues), 55.6 bits, see alignment E=9.3e-19 PF04253: TFR_dimer" amino acids 643 to 758 (116 residues), 76.1 bits, see alignment E=3.5e-25

Best Hits

KEGG orthology group: K01301, glutamate carboxypeptidase II [EC: 3.4.17.21] (inferred from 52% identity to dfe:Dfer_1367)

Predicted SEED Role

"Glutamate carboxypeptidase II (EC 3.4.17.21)" (EC 3.4.17.21)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.17.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (769 amino acids)

>LRK53_RS12905 M28 family peptidase (Rhodanobacter sp000427505 FW510-R12)
MTRSALRPLLSLGCLLAAFAAAAASPADRTDAAALFGFSASAATAQQDLERRFDAQLDPA
ELRGWLKQMASQPNQVGSPHDKANAEFILSKFREWGWNAHIETFSVLYPTPKKVALELLG
PKPYVAALHEPAIEGDATSGLAGVLPPYNVYGADGDVSAPLVYANYGMPDDYKELARRGI
DVRGKIVLTRYGHGWRGLKPKLAQEHGAVGCLIYSDPHDDGYAMGDVYPQGGWRPAQGVQ
RGSVADMQLYPGDPLTPGIGSTPGAKRLALKDAKTILKIPVLPISYADATPLLQALAGPV
APAGWRGALPLTYRVGPSAANVHLTVQSDWKQQPVYDVIATIEGSAEPDQWIVRGNHHDG
WTFGAWDPLSGTIALMAEAKAIGGLVKQGWRPQRTLVYASWDGEEPGLLGSTEWAETHAA
ELQQKAVLYLNSDTNGRGFLGAGGSHSLQHLVNQVAAGVTDPETGVSVRERLRAHMQVAG
NNKDAKPEVKAIAKLAAAGGDLPLAALGSGSDYSAFLEHLGIASLDLGFGGEDDDGGIYH
SRYDSFDHYARFGDPSFDYGMALAKVAGHVMLRSAEANVLPLRFGDFSDTLGRYLDELHK
LVDDTREATERQHQLLDSHAFALNADPTRPVAPPARDSDMPAIDLAPLDRAAKRLAQSAK
ACRAAYDKRAAAGFNLTAAQRQQLDRLAGSMEQRLTDPAGLPGRSWFKHFIYAPGMLTGY
DVKTVPGVREAIEARRWDEASHYAALTAKVLDRYRAQLDQLTALLDKQS