Protein Info for LRK53_RS12705 in Rhodanobacter sp000427505 FW510-R12

Annotation: cytochrome c biogenesis heme-transporting ATPase CcmA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 212 TIGR01189: heme ABC exporter, ATP-binding protein CcmA" amino acids 11 to 200 (190 residues), 200 bits, see alignment E=1.6e-63 PF00005: ABC_tran" amino acids 28 to 165 (138 residues), 94.7 bits, see alignment E=7.5e-31

Best Hits

Swiss-Prot: 58% identical to CCMA_XANC8: Cytochrome c biogenesis ATP-binding export protein CcmA (ccmA) from Xanthomonas campestris pv. campestris (strain 8004)

KEGG orthology group: K02193, heme exporter protein A [EC: 3.6.3.41] (inferred from 58% identity to xcc:XCC2219)

Predicted SEED Role

"ABC transporter involved in cytochrome c biogenesis, ATPase component CcmA" in subsystem Biogenesis of c-type cytochromes

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (212 amino acids)

>LRK53_RS12705 cytochrome c biogenesis heme-transporting ATPase CcmA (Rhodanobacter sp000427505 FW510-R12)
MTAADTALPLLEARALSFFRQDEPVFAPLDFRLHAGELALVEGDNGSGKTTLLRMLAGLL
HITAGELHWHGEPMQRDRCAGEILFLGHQLGLKADLSPRENLRIAAGLHGVRDDGTSAAS
VLARIGLRGYEDEPVRRLSAGQKKRAALARLLLLPASLWLLDEPYANLDRIGIALVNELL
ESHTDTGGAAMVTSHGTVSFHGGEPRRIRMHD